维生素B_(6)的合成代谢及其生产应用  

Synthesis Metabolism and Production Application of Vitamin B_(6)

作　　者：李丹妮 郑忠亮[1] LI Danni;ZHENG Zhongliang(College of Life Sciences,Wuhan University,Wuhan 430072,China)

机构地区：[1]武汉大学生命科学学院,湖北武汉430072

出　　处：《华侨大学学报（自然科学版）》2024年第5期588-595,共8页Journal of Huaqiao University(Natural Science)

基　　金：国家自然科学基金资助项目(30800190,81372441)。

摘　　要：为了得到环保、便捷且效率更高的维生素B_(6)代谢生产途径,综述了维生素B_(6)作为重要的生物活性小分子在不同生物体中参与的天然合成代谢途径及目前研究发现的偶然代谢途径;同时,总结了利用生物酶法与代谢工程生产维生素B_(6)的生物合成法。结果表明:通过生物合成维生素B_(6)可以代替化学合成法,但未来仍需要研究者对代谢途径进行不断优化、筛选,以得到更高产量的维生素B_(6)。In order to achieve an environmentally friendly,convenient,and more efficient metabolic production pathway for vitamin B_(6),the natural metabolic and serendipitous pathways of vitamin B_(6)as an important bioactive small molecule in various organisms are comprehensively reviewed.Additionally,the biosynthesis method of vitamin B_(6)production by enzyme and metabolic engineering techniques is summarized.The results indicate that biosynthesis can serve as an alternative method to chemical synthesis for producing vitamin B_(6).However,further research is needed to continuously optimize and screen the metabolic pathway to obtain higher yields of vitamin B_(6).

关 键 词：维生素B_(6) 系统代谢工程 偶然途径 酶催化 

分 类 号：Q56[生物学—生物化学]