干细胞聚合体构建方法与牙再生应用现状  

Stem cell aggregate construction methods and current applications in dental regeneration

作　　者：金岩 邢哲嘉 何珺希 郑晨曦 隋秉东 JIN Yan;XING Zhe-jia;HE Jun-xi;ZHENG Chen-xi;SUI Bing-dong(National Key Laboratory of Reconstruction and Regeneration of Oral and Maxillary System,National Clinical Medical Research Center for Oral Diseases,Shaanxi International Joint Research Center for Oral Diseases,Tissue Engineering R&D Center of the Third Affiliated Hospital of Air Force Medical University,Xi’an 710032,China;不详)

机构地区：[1]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病国际联合研究中心,空军军医大学第三附属医院组织工程研发中心,陕西西安710032 [2]空军军医大学基础医学院,陕西西安710032 [3]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学第三附属医院正畸科,陕西西安710032

出　　处：《牙体牙髓牙周病学杂志》2024年第2期63-69,共7页Chinese Journal of Conservative Dentistry

摘　　要：牙缺损和牙缺失是口腔健康领域常见的临床问题,传统的治疗方法如义齿和种植体仍存在诸多局限性。近年来,随着干细胞研究和组织工程技术的发展,再生医学为牙再生与修复提供了新的希望。其中,间充质凝聚是器官形态发育中的关键初期事件,基于其原理,体外工程化构建的干细胞聚合体已被成功应用于牙髓、牙本质、牙周等多种组织的再生修复。本文将从干细胞聚合体的理论基础、构建方法以及其在牙再生领域的应用现状进行探讨,旨在为进一步理解干细胞聚合体的生物学基础及其在牙再生领域的应用提供理论支持和实验指导。Tooth loss and defects are common clinical issues in the field of oral health,and traditional treat⁃ment methods such as dentures and implants still have numerous limitations.In recent years,with the advancement of stem cell research and tissue engineering technology,regenerative medicine has offered new hope for tooth regeneration and re⁃pair.Among these,mesenchymal condensation,a crucial initial event in organ morphogenesis,has been utilized to recon⁃struct engineered stem cell aggregates in vitro.These aggregates have been successfully applied to regenerate and repair various dental tissues,including dental pulp,dentin,and periodontal tissue.This article aims to delve into the theoretical foundation,construction methods,and current applications of stem cell aggregates in the field of tooth regeneration.The ob⁃jective is to provide theoretical support and experimental guidance for a deeper understanding of the biological bases of stem cell aggregates and their use in tooth regeneration.

关 键 词：间充质干细胞 间充质凝聚 干细胞聚合体 牙再生 

分 类 号：R783.4[医药卫生—口腔医学]