依达拉奉联合尼莫地平对脑动脉瘤术后脑血管痉挛患者血管内皮功能及脑动脉血流速度的影响  

Effects of edaravone combined with nimodipine on vascular endothelial function and cerebral artery fl ow velocity in patients with cerebral vasospasm after cerebral aneurysm surgery

作　　者：李元富 潘海鹏 Li Yuanfu;Pan Haipeng(Department of Pharmacy,363 Hospital,Chengdu Sichuan 610097,China;Department of Neurosurgery,363 Hospital,Chengdu Sichuan 610097,China)

机构地区：[1]四川省三六三医院药剂科,四川成都610097 [2]四川省三六三医院神经外科,四川成都610097

出　　处：《中国医刊》2024年第10期1109-1112,共4页Chinese Journal of Medicine

基　　金：四川省医学科研课题计划(S20065)。

摘　　要：目的探讨依达拉奉联合尼莫地平对脑动脉瘤术后脑血管痉挛患者血管内皮功能及脑动脉血流速度的影响。方法选取2021年5月至2023年5月四川省三六三医院收治的80例脑动脉瘤术后脑血管痉挛患者为研究对象,采用随机数字表法将研究对象分为单药组(给予尼莫地平治疗,40例)和联合组(给予依达拉奉联合尼莫地平治疗,40例)。两组患者均连续治疗2周。比较分析两组患者治疗2周后的临床疗效。比较分析两组患者治疗前后的神经功能缺损程度(NIHSS评分)、意识障碍严重程度(GCS评分)及日常生活活动能力(BI评分),脑动脉血流速度[大脑中动脉最大峰值血流速度(MPV)、平均血流速度(Vm)],血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)]以及治疗过程中的不良反应发生情况。结果联合组患者治疗2周后的临床总有效率高于单药组,差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗2周后的NIHSS评分、ET-1均降低,且联合组低于单药组,差异均有统计学意义(P<0.05);GCS评分、BI评分、大脑中动脉MPV、大脑中动脉Vm、NO均升高,且联合组高于单药组,差异均有统计学意义(P<0.05)。两组患者治疗过程中的不良反应总发生率比较差异无统计学意义(P>0.05)。结论依达拉奉联合尼莫地平治疗脑动脉瘤术后脑血管痉挛患者的临床疗效显著,可改善患者的血管内皮功能及脑动脉血流速度,且安全性较好。Objective To explore the effects of edaravone combined with nimodipine on vascular endothelial function and cerebral artery flow velocity in patients with cerebral vasospasm after cerebral aneurysm surgery.Method 80 patients with cerebral vasospasm after cerebral aneurysm surgery in 363 Hospital in Sichuan Province from May 2021 to May 2023 were selected as the study objects.They were divided into single drug group(nimodipine treatment,40 cases)and combination group(edaravone combined with nimodipine treatment,40 cases)by random number table method.Two groups were treated continuously for two weeks.The clinical effi cacy in the two groups after two weeks was compared and analyzed.Neurological impairment(NIHSS score),consciousness disorder severity(GCS score),activity of daily living(BI score),cerebral artery blood flow velocity(MPV),average blood flow velocity(Vm),vascular endothelial function(ET-1,NO)before and after treatment,and the occurrence of adverse reactions during treatment in the two groups were compared and analyzed.Result After two weeks of treatment,the total clinical effective rate in the combination group was higher than that in the single drug group,with statistical significance(P<0.05).Compared with before treatment,NIHSS score and ET-1 in two groups after two weeks of treatment were decreased,and combination group was lower than single drug group,with statistical significance(P<0.05),and GCS score,BI score,MPV of middle cerebral artery,Vm of middle cerebral artery,NO were all increased,and combination group was higher than single drug group,with statistical significance(P<0.05).There was no signifi cant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effi cacy of edaravone combined with nimodipine in the treatment of patients with cerebral vasospasm after cerebral aneurysm surgery is signifi cant,which can improve the vascular endothelial function and cerebral artery flow velocity,with good safety.

关 键 词：依达拉奉 尼莫地平 脑动脉瘤 脑血管痉挛 血管内皮功能 脑动脉血流速度 

分 类 号：R743[医药卫生—神经病学与精神病学]