缓解期溃疡性结肠炎早期复发的影响因素分析  

Analysis of Influencing Factors of Early Recurrence of Ulcerative Colitis in Remission

作　　者：郑文凤 王戊辰 李山林[1] 刘学进[1] ZHENG Wen-feng;WANG Wu-chen;LI Shan-Lin;LIU Xue-Jin(Department of Gastroenterology,Zhoukou Central Hospital,Zhoukou,Henan 466000)

机构地区：[1]周口市中心医院消化内科,河南周口466000

出　　处：《中国肛肠病杂志》2024年第8期47-49,共3页Chinese Journal of Coloproctology

摘　　要：目的:探讨缓解期溃疡性结肠炎(UC)早期复发的影响因素。方法:选择2021年1月至2023年5月治疗后处于UC缓解期1周内的200例患者为研究对象,采集粪便进行钙卫蛋白(FC)检测,并行结肠镜检查。前瞻性随访至少3个月,监测患者早期复发情况。分析缓解期UC早期复发的影响因素。结果:200例患者中,早期复发50例(25.0%)。在性别、临床分型、白细胞计数、C反应蛋白及粪便FC水平方面,复发组与未复发组均有明显差异,P<0.05。Logistic多元回归分析显示,性别、临床分型及粪便FC水平是缓解期UC患者早期复发的独立影响因素,P<0.05。结论:缓解期UC早期复发率较高,除性别和临床分型外,粪便FC升高是缓解期UC早期复发的独立危险因素,监测FC水平对于筛选缓解期UC早期复发倾向者具有一定指导意义。Objective To investigate the factors influencing the early recurrence of ulcerative colitis(UC)in remission.Methods Total 200 patients who were in remission of UC within 1 week after treatment from January 2021 to May 2023 were selected as the study objects.Fecal samples were collected for calprotectin(FC)detection,and colonoscopy was performed.The patients were prospectively followed up for at least 3 months to monitor for early recurrence.The factors influencing the early recurrence of UC in remission were analyzed.Results Among 200 patients,50 cases(25.0%)had early recurrence.There were significant differences in gender,clinical classification,white blood cell count,C-reactive protein and FC level between the recurrence group and the non-recurrence group(P<0.05).Logistic multiple regression analysis showed that gender,clinical classification and FC level were the independent factors for early recurrence of UC patients in remission(P<0.05).Conclusion The early recurrence rate of UC in remission is high.In addition to gender and clinical classification,the increase of FC is an independent risk factor for the early recurrence of UC in remission.Monitoring FC level has certain guiding significance for screening the early recurrence tendency of UC in remission.

关 键 词：溃疡性结肠炎 钙卫蛋白 早期复发 相关性 

分 类 号：R574.62[医药卫生—消化系统]