增强CT联合血清DSG2对食管鳞状细胞癌的诊断价值研究  

Diagnostic Value of Enhanced CT Combined with Serum DSG2 in Esophageal Squamous Cell Carcinoma

作　　者：陈金金 陈东旭 张仲伟[1] CHEN Jin-jin;CHEN Dong-xu;ZHANG Zhong-wei(Department of Radiology,Wuxi Branch of Ruijin Hospital Affiliated to Shanghai Jiao TongUniversity School of Medicine/Wuxi Xinwu District Xinrui Hospital,Wuxi 214104,JiangsuProvince,China;Department of Nuclear Medicine,Wuxi Branch of Ruijin Hospital Affiliated to Shanghai JiaoTong University School of Medicine/Wuxi Xinwu District Xinrui Hospital,Wuxi 214104,JiangsuProvince,China)

机构地区：[1]上海交通大学医学院附属瑞金医院无锡分院/无锡市新吴区新瑞医院放射科 [2]上海交通大学医学院附属瑞金医院无锡分院/无锡市新吴区新瑞医院核医学科,江苏无锡214104

出　　处：《中国CT和MRI杂志》2024年第9期85-87,共3页Chinese Journal of CT and MRI

基　　金：江苏省卫生健康委医学科研立项项目(2022-217)。

摘　　要：目的探讨增强CT联合血清桥粒芯蛋白2(DSG2)对食管鳞状细胞癌(ESCC)的诊断价值研究。方法回顾性分析2020年1月至2022年12月本院收治的68例ESCC患者(ESCC组)以及同期42例食管平滑肌瘤患者(食管平滑肌瘤组)的临床资料,均行增强CT检查、血清DSG2水平检测。比较两组间增强CT特征、血清DSG2水平差异。通过绘制受试者工作特征曲线(ROC)分析增强CT特征、血清DSG2水平诊断ESCC的效能。结果ESCC组肿瘤位于食管胸中段、范围超过食管壁1/2、边缘不光滑、周围间隙不清晰以及淋巴结转移所占比例、血清DSG2水平显著高于食管平滑肌瘤组(P<0.05),而ESCC组与食管平滑肌瘤组之间强化方式、坏死区域以及溃疡所占比例差异无统计学意义(P>0.05);与单独诊断相比较,增强CT特征联合血清DSG2水平对ESCC评估的AUC、约登指数、敏感度、特异度最高。结论增强CT特征联合血清DSG2水平对ESCC的诊断具有更高的评估价值,可为ESCC的临床诊断与治疗提供依据。Objective To investigate the diagnostic value of enhanced CT combined with serum desmoglein 2(DSG2)in esophageal squamous cell carcinoma(ESCC).Methods Retrospective analysis of the clinical data of 68 ESCC patients(ESCC group)and 42 esophageal leiomyoma patients(esophageal leiomyoma group)admitted to our hospital from January 2020 to December 2022,all of whom underwent enhanced CT examination and serum DSG2 level detection.Compare the differences in enhanced CT features and serum DSG2 levels between the two groups.The efficacy of enhanced CT features and serum DSG2 levels in the diagnosis of ESCC was analyzed by drawing the receiver operating characteristic curve(ROC).Results The proportion of tumors located in the middle thoracic segment of the esophagus,with an area exceeding 1/2 of the esophageal wall,unsmooth edges,unclear peripheral spaces,and lymph node metastasis,and the level of serum DSG2 in the ESCC group were significantly higher than those in the esophageal leiomyoma group(P<0.05).However,there was no statistically significant difference between the ESCC group and the esophageal leiomyoma group in the enhancement pattern,necrotic regions,and the proportion of ulcers(P>0.05);Compared with individual diagnosis,enhanced CT features combined with serum DSG2 levels have the highest AUC,Yoden index,sensitivity,and specificity for ESCC evaluation.Conclusion Enhanced CT features combined with serum DSG2 levels have higher evaluation value in the diagnosis of ESCC,providing evidence for clinical diagnosis and treatment.

关 键 词：增强CT 血清桥粒芯蛋白2 食管鳞状细胞癌 诊断价值 

分 类 号：R571[医药卫生—消化系统]