大剂量维生素C联合FOLFOX6治疗结直肠癌的临床疗效  

Clinical effect of high-dose vitamin C combined with FOLFOX6 for colorectal cancer

作　　者：孙龙凤 王志超[1] 戴猛 樊跃平 饶本强 Sun Longfeng;Wang Zhichao;Dai Meng;Fan Yueping;Rao Benqiang(Department of Digestive Surgery,Gastroenterology Centre,Aviation General Hospital,Beijing 100012,China;General Surgery,Aviation General Hospital,Beijing 100012,China;Center for Oncology Nutrition and Metabolism,Beijing Shijitan Hospital,Capital Medical University/Key Laboratory of Cancer FSMP for State Market Regulation,Beijing 100038,China)

机构地区：[1]航空总医院消化病中心消化外科,北京100012 [2]航空总医院普通外科,北京100012 [3]首都医科大学附属北京世纪坛医院肿瘤营养与代谢中心,国家肿瘤市场监管重点实验室,北京100038

出　　处：《肿瘤代谢与营养电子杂志》2024年第4期499-504,共6页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金面上项目(82474333)。

摘　　要：目的探究大剂量维生素C联合FOLFOX6治疗结直肠癌的临床疗效。方法回顾性分析2016年4月至2017年9月于航空总医院就诊的58例结直肠癌患者的临床资料。按照治疗方式分为:试验组(采用大剂量维生素C联合FOLFOX6治疗,n=29例)和对照组(单用FOLFOX6治疗,n=29例)。比较两组之间的治疗效果、不良反应及对于患者生活质量的改善情况。结果试验组总有效率为58.6%,对照组总有效率为44.8%,差异有统计学意义(P<0.05);两组患者治疗后肿瘤标志物癌胚抗原(CEA)和糖类抗原19-9(CA19-9)水平显著低于治疗前(P<0.05),且试验组较对照组的变化更为明显(P<0.05);相比对照组,试验组在消化道和骨髓抑制方面的不良反应明显减轻,差异均有统计学意义(P<0.05)。试验组的好转率为62.06%,明显高于对照组的好转率(48.27%),差异有统计学意义(P<0.05)。结论大剂量维生素C联合FOLFOX6治疗结直肠癌与单纯使用FOLFOX6治疗结直肠癌相比较,可取得显著临床疗效,还可以降低化疗不良反应,改善患者生活质量。Objective To investigate the clinical effect of high-dose vitamin C combined with FOLFOX6 chemotherapy for colorectal cancer.Method The clinical data of 58 patients with colorectal cancer admitted to Aviation General Hospital from April 2016 to September 2017 were retrospectively analyzed.According to the treatment methods,they were divided into experimental group(treated with high-dose vitamin C combined with FOLFOX6 chemotherapy,n=29 cases)and control group(treated with FOLFOX6 chemotherapy alone,n=29 cases).The effects of treatment,adverse reactions,and improvements in patients′quality of life were compared between the two groups.Result The effective rate was 58.6%in the experimental group and 44.8%in the control group,with statistically significant differences(P<0.05).After treatment,tumor marker carcinoembryonic antigen and tumor marker carbohydrate antigen 19-9 concentrations in 2 groups were significantly decreased after treatment(P<0.05),and the decrease in experimental group was more obvious than control group(P<0.05).The adverse reactions of digestive tract reaction and bone marrow suppression were significantly reduced in the experimental group,and the differences between the two adverse reactions were statistically significant(P<0.05).The improvement rate of experimental group was 62.06%,which was significantly higher than that of control group(48.27%),and the difference was statistically significant(P<0.05).Conclusion Compared with FOLFOX6 chemotherapy alone,high-dose vitamin C combined with FOLFOX6 chemotherapy in the treatment of colorectal cancer can achieve significant clinical efficacy,reduce the adverse reactions of chemotherapy,and improve the quality of life of patients,which has high clinical value.

关 键 词：大剂量维生素C 结直肠癌 奥沙利铂 亚叶酸钙 5-氟尿嘧啶 疗效 肿瘤标志物 不良反应 

分 类 号：R735.34[医药卫生—肿瘤]