食管癌患者围化疗期症状群调查  

Changes of symptom groups in patients with esophageal cancer during chemotherapy and its implications

作　　者：徐春明[1] 江静 冒小平[3] Xu Chunming;Jiang Jing;Mao Xiaoping(Department of Radiotherapy,Nantong Cancer Hospital,Nantong 226361,Jiangsu,China;Department of Radiology,Hai'an Hospital of Traditional Chinese Medicine,Hai'an 226600,Jiangsu,China;Department of Internal Medicine,Nantong Cancer Hospital,Nantong 226361,Jiangsu,China)

机构地区：[1]南通市肿瘤医院放疗科,江苏南通226361 [2]海安市中医院放射科,江苏海安226600 [3]南通市肿瘤医院内科,江苏南通226361

出　　处：《肿瘤代谢与营养电子杂志》2024年第4期512-518,共7页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：江苏省“六大人才高峰”高层次人才选拔培养资助项目(WSW-058)2022年度南通市卫生健康委员会科研课题(MSZ2022075)。

摘　　要：目的探索食管癌患者围化疗期间症状群构成及动态变化,为其化疗期间症状管理提供依据。方法选取2021年6月至2022年12月南通市肿瘤医院肿瘤中心治疗的食管癌化疗患者168例作为研究对象,采用基本信息调查表、安德森症状测评量表、症状补充问卷分别在首次入院(T1)、首次化疗(T2)、第2次化疗(T3)、末次化疗(T4)时进行问卷调查。提取症状群使用探索性因子分析。结果T1~T4时间节点的症状发生率>20%的数目分别为12、20、22、18个。症状发生率12.50%~94.12%。探索性因子分析结果:食管癌患者围化疗期间在T1~T4时间节点分别提取症状群个数3、5、6、6个。其中,睡眠紊乱症状群、认知相关症状群、心理神经症状群持续存在于T1~T4时间节点,疼痛症状群、消化道症状群存在于T2~T4时间节点,活动耐力症状群存在于T3~T4时间节点。结论食管癌患者化疗期间存在多种症状,T3、T4时间节点的症状群构成较为稳定。临床工作人员应关注食管癌患者化疗期间的症状群,并采取相应措施积极进行干预以缓解多种症状,进而降低症状群对患者的影响。Objective To explore the symptom group composition and dynamic change track of patients with esophageal cancer during chemotherapy,and provide evidence for symptom management of patients with esophageal cancer during chemotherapy.Method A total of 168 patients with esophageal cancer treated by chemotherapy in Nantong Cancer Hospital from June 2021 to December 2022 were selected as the study objects.General data questionnaire,Anderson symptom assessment scale and symptom supplement questionnaire were used at the first admission(T1),first chemotherapy(T2),second chemotherapy(T3)and last chemotherapy(T4).Symptom cluster were extracted by exploratory factor analysis.Result There were 12,20,22 and 18 symptoms with an incidence greater than 20%at each time node from T1 to T4,respectively.The incidence ranged from 12.50%to 94.12%.Exploratory factor analysis revealed:Three,five,six and six symptom cluster were extracted from T1,T2,T3 and T4 respectively during chemotherapy for patients with esophageal cancer.Among them,sleep disorder symptom group,cognitive-related symptom group and psychoneurotic symptom group persisted from T1 to T4,pain symptom group,digestive tract symptom group existed from T2-T4.Activity tolerance symptom group existed in T3-T4.Conclusion Patients with esophageal cancer have multiple symptoms and high incidence during chemotherapy,and the composition of T3 and T4 symptom cluster is relatively stable.Nurses should pay attention to the symptom cluster of postoperative patients with esophageal cancer during chemotherapy,and take appropriate measures to actively intervene to alleviate various symptoms,so as to reduce the impact on patients.

关 键 词：食管癌 化疗期间 症状群 纵向研究 症状负担 睡眠紊乱 认知 疼痛 

分 类 号：R735.1[医药卫生—肿瘤]