肺癌化疗患者味觉改变与其营养状况及癌因性疲乏的相关性研究  

The relation of taste change,nutritional status and cancer fatigue in lung cancer chemotherapy

作　　者：黄文霞[1] 柏倩雯 钱静 朱洁[2] Huang Wenxia;Bai Qianwen;Qian Jing;Zhu Jie(Department of Oncology,Suzhou Hospital of Traditional Chinese Medicine,Suzhou 215008,Jiangsu,China;Blood Purification Center,Suzhou Hospital of Traditional Chinese Medicine,Suzhou 215008,Jiangsu,China)

机构地区：[1]苏州市中医医院肿瘤科,江苏苏州215008 [2]苏州市中医医院血液净化中心,江苏苏州215008

出　　处：《肿瘤代谢与营养电子杂志》2024年第4期566-570,共5页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：苏州市科技发展计划项目(SYSD2019158)。

摘　　要：目的探索肺癌化疗患者味觉改变与其营养状况及癌因性疲乏的相关性。方法回顾性分析苏州市中医医院2021年2月至2024年2月期间收集的137例肺癌化疗患者,应用化疗相关味觉改变量表(CiTAS)、营养风险筛查2002(NRS 2002)、癌因性疲乏(CFS)状态进行评估,经Pearson法和线性回归分析CiTAS评分、NRS 2002评分、CFS评分相关性,同时,经中介效应分析三者的关系。结果肺癌化疗患者的基本味觉改变评分(15.52±2.52)分、味觉异常和味幻觉(9.12±2.63)分、进食困扰(20.15±2.35)分、整体味觉改变(12.35±2.89)分、CiTAS总分(57.13±7.78)分,NRS 2002评分(4.89±2.22)分,躯体疲乏(24.86±2.84)分、情感疲乏(12.36±2.39)分、认知疲乏(11.78±2.55)分、CFS总分(49.01±6.60)分。经Pearson法分析,Ci-TAS总分与NRS 2002评分,躯体疲乏、情感疲乏、认知疲乏、CFS总分呈正相关;经线性回归分析,NRS 2002评分、CiTAS总分会影响CFS总分;经中介效应分析,NRS 2002评分(β=0.469,P<0.001)与CiTAS总分(β=1.105,P<0.001)均可以显著正向预测CFS总分;CiTAS总分在NRS 2002评分、CFS总分影响中起到部分中介作用,中介效应占总效应比例的21.17%。结论肺癌化疗患者味觉改变症状明显,处于中重度水平,且会直接影响营养状况及癌因性疲乏,味觉改变越严重,营养状态、癌因性疲乏越严重,呈正相关,对此需积极开展营养治疗,调整食物口味,适应患者味觉需求,以保证足够营养摄入,改善身心健康状态。Objective To explore the correlation between taste change,its nutritional status and cancer fatigue in lung cancer chemotherapy patients.Method Retrospective analysis of 137 patients with lung cancer chemotherapy,collected in Suzhou Hospital of Traditional Chinese Medicine from February 2021 to February 2024 for chemotherapy-related taste change scale(CiTAS),nutritional risk screening(NRS 2002),cancer fatigue(CFS)status assessment,Pearson method and linear regression analysis of CiTAS score,NRS 2002 score,and CFS score.Result Basic taste change score(15.52±2.52),taste abnormalities and taste hallucinations(9.12±2.63),eating distress(20.15±2.35),overall taste change(12.35±2.89),CiTAS score(57.13±7.78),NRS 2002 score(4.89±2.22),physical fatigue(24.86±2.84),emotional fatigue(12.36±2.39),cognitive fatigue(11.78±2.55),CFS score(49.01±6.60)points.Analyzed by the Pearson method,total score of CiTAS was positively correlated with NRS 2002 score,physical fatigue,emotional fatigue,cognitive fatigue,and CFS total score;After a linear regression analysis,NRS 2002 The score and the total CiTAS score will affect the total CFS score;By the analysis of the mediation effect,NRS 2002 Score(β=0.469,P<0.001)and total CiTAS score(β=1.105,P<0.001)can significantly and positively predict the total CFS score;The CiTAS total score plays a partial mediating role in the influence of NRS 2002 score and CFS total score,the mediation effect accounted for 21.17%of the total effect proportion.Conclusion Lung cancer chemotherapy patients taste change symptoms,moderate to severe level,and will directly affect the nutrition and cancer fatigue,taste change the more serious,nutritional status,cancer fatigue the more serious,a positive correlation,to actively develop nutrition support,adjust food taste,to meet the demand of patients,to ensure enough nutrition intake,improve physical and mental health.

关 键 词：肺癌 化疗 味觉改变 营养状况 癌因性疲乏 营养治疗 化疗相关味觉改变量表 营养风险筛查表 

分 类 号：R735.2[医药卫生—肿瘤] R459.3[医药卫生—临床医学]