不同种类全瓷冠对龈沟液IL-1β、MMP-8的影响  

Effects of different kinds of all-porcelain crowns on the levels of IL-1βand MMP-8 in gingival cevicular fluid

作　　者：王璐 崔玉兰[1,3] 吴洁[1,3] 张钊[1,3] WANG Lu;CUI Yu-Lan;WU Jie;ZHANG Zhao(School of Stomatology,Hebei Medical University,Hebei medical university Hebei Key Laboratory of Stomatology,Hebei Clinical Research Center for Oral Diseases,Hebei 050017,China;不详)

机构地区：[1]河北医科大学口腔医学院,河北医科大学河北省口腔医学重点实验室,河北省口腔疾病临床医学研究中心,河北石家庄050017 [2]唐山职业技术学院附属医院口腔科,河北唐山063000 [3]河北医科大学口腔医学院·口腔医院修复科,河北石家庄050017

出　　处：《牙体牙髓牙周病学杂志》2024年第3期147-150,155,共5页Chinese Journal of Conservative Dentistry

基　　金：河北省财政厅2020年政府资助临床医学优秀人才培养项目(2020048149-2);河北省财政厅老年病防治科研项目(361029)。

摘　　要：目的:探究二硅酸锂玻璃陶瓷冠(铸瓷冠)及氧化锆全瓷冠(全锆冠)修复前后龈沟液内标志物白细胞介素(IL)-1β、基质金属蛋白酶(MMP)-8的差异。方法:选取行全冠修复的24名患者共30个牙齿为研究对象,依全冠材料分为铸瓷冠组和全锆冠组,每组各15例。在修复前、修复后1、3、6个月时,测量两组修复牙及对侧同名天然牙的牙周探诊深度,采集修复牙龈沟液,采用酶联免疫反应方法检测龈沟液中IL-1β、MMP-8浓度,并进行统计学分析。结果:铸瓷冠及全锆冠组修复前、后不同时间,牙周探诊深度及龈沟液中MMP-8无统计学差异(P>0.05)。全锆冠组修复前后龈沟液中IL-1β无显著变化(P>0.05);铸瓷冠组组内不同时间比较,龈沟液IL-1β在3个月时表达最高,显著高于修复后1个月(P<0.05)。全锆冠组与铸瓷冠组组间相比,在修复后3个月及6个月时,铸瓷冠组龈沟液中IL-1β显著高于全锆冠组(P<0.05)。结论:全锆冠修复后龈沟液中生物标志物变化不明显,铸瓷冠较全锆冠对牙周组织产生影响更大。AIM:To compare the difference of levels of interleukin(IL)-1βand matrix metalloproteinase(MMP)-8 in gingival crevicular fluid before and after lithium disilsilicate reinforced glass ceramic crown(castable ceramic crown)and zirconia all-ceramic crown(zirconia crown)restoration.METHODS:A total of 30 teeth from 24 patients with crown restoration were selected as the study objects,and were divided into castable ceramic crown group and zirconia crown group according to materials,with 15 teeth in each group.At 1,3 and 6 months after restoration,periodontal probing depth of the two groups of restored teeth and the opposite natural teeth with the same name were measured,gingival crevicu-lar fluid was collected to detect concentrations of IL-1βand MMP-8 in gingival crevicular fluid by enzyme-linked immu-noreaction method,then statistical analysis was performed.RESULTS:There was no statistic difference in periodontal probing depth and levels of MMP-8 in gingival crevicular fluid between castable ceramic crown and zirconia crown group before and after restoration(P>0.05).There was no significant change of IL-1βin gingival crevicular fluid before and after restoration in zirconia crown group(P>0.05).In castable ceramic crown,the expression of IL-1βwas the highest at 3 months,which was significantly higher than that at 1 month after repair(P<0.05).The IL-1βcontent in gingival crevicular fluid of the castable ceramic crown group was significantly higher than that of the zirconia crown group at 3 and 6 months after restoration(P<0.05).CONCLUSION:There is no significant change of biomarkers in gingival cevicular fluid after zirconia all-ceramic crown restoration.lithium disilsilicate reinforced glass ceramic crown has more effect on periodontal tissue than zirconia crown restoration.

关 键 词：全锆冠 铸瓷冠 白细胞介素-1Β 基质金属蛋白酶-8 龈沟液 

分 类 号：R783.3[医药卫生—口腔医学]