环境肿瘤学研究方法进展  

Advances in research methods of environmental oncology

作　　者：党欣欣 刘杰[2,4,5,6] 景丽百合[4,5,6] 李玉民 Dang Xinxin;Liu Jie;Jing Libaihe;Li Yumin(Department of Special Medicine,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Surgical Oncology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of General Surgery,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Environmental Oncology Center,Lanzhou University,Lanzhou 730030,China;Tumor Transformation and Innovation Engineering Center,Lanzhou University,Lanzhou 730030,China;Department of Clinical Technology,The Second Clinical Clinical School,Lanzhou University,Lanzhou 730030,China;Gansu Provincial Key Laboratory of Environmental Oncology,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院特需内科,甘肃兰州730030 [2]兰州大学第二医院肿瘤外科,甘肃兰州730030 [3]兰州大学第二医院普通外科,甘肃兰州730030 [4]兰州大学环境肿瘤学中心,肃兰州730030 [5]兰州大学消化系肿瘤转化与创新工程中心,甘肃兰州730030 [6]兰州大学第二临床医学院临床技能教研室,甘肃兰州730030 [7]甘肃省环境肿瘤学重点实验室,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2024年第8期87-94,共8页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金资助项目(31770537);甘肃省首席科学家项目(22JR9KA002);甘肃省重点研发计划资助项目(20ZD7FA003);甘肃省教育厅资助项目(2021jyjbgs-02)。

摘　　要：环境肿瘤学作为一门新兴的交叉学科,采用多学科交叉融合的方法,研究肿瘤的环境因素,为肿瘤防控提供科学依据。本文系统介绍环境流行病学、临床环境流行病学和实验室研究等常用研究方法;详细阐述分子流行病学、高通量组学和基因环境交互作用研究等新兴研究方法;探讨大数据与人工智能对环境肿瘤学研究的价值;强调了环境致癌风险评价、地理信息系统和遥感技术对环境暴露研究的作用;指出了环境肿瘤学研究方法未来的发展方向和挑战。As a new interdisciplinary discipline,environmental oncology adopts an interdisciplinary fusion method to study the environmental factors of tumors and provide a scientific basis for tumor prevention and control.Introduced systematically in this paper were the conventional research methods in environmental epi-demiology,clinical environmental epidemiology and laboratory research.Modern research methods such as molecular epidemiology,high-throughput omics and gene-environment interaction were described in detail.In particular,the value of big data and artificial intelligence for research in environmental oncology was dis-cussed.The effects of environmental carcinogenic risk assessment,geographic information system and remote sensing technology on environmental exposure research were emphasized.The future development direction and challenges for environmental oncology research methods were pointed out.

关 键 词：环境肿瘤学 研究方法 多学科交叉 分子流行病学 

分 类 号：R73[医药卫生—肿瘤]