SHIP1在肿瘤发生发展及免疫调节中的作用  

Role of SHIP1 in tumorigenesis,development and immune regulation

作　　者：沈宇杰 徐盈 杨红 李佳 李远凤 陈志浩 冯忘忧 陈紫均 SHEN Yujie;XU Ying;YANG Hong;LI Jia;LI Yuanfeng;CHEN Zhihao;FENG Wangyou;CHEN Zijun(Department of Obstetrics and Gynecology,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学西京医院妇产科,陕西西安710032

出　　处：《空军军医大学学报》2024年第9期1062-1066,共5页Journal of Air Force Medical University

基　　金：国家自然科学基金(82172993);陕西省自然科学基础研究计划项目(2022JQ-977)。

摘　　要：含有SH2区域的肌醇5′磷酸酶1(SHIP1)是一类主要但不完全表达在造血源性细胞胞质中的磷酸酶蛋白,属于肌醇5′磷酸酶家族,是磷脂酰肌醇3激酶(PI3K)信号通路的重要负性调控因子。PI3K信号通路已被证明在肿瘤的发生发展中起作用,而SHIP1作为磷酸肌醇信号通路的调节因子,是肿瘤发生发展和免疫调节中不容小觑的一环。本文旨在总结SHIP1在肿瘤发生发展和免疫调节中的作用,以探寻肿瘤治疗新途径。The SH2-containing inositol 5-phosphatase 1(SHIP1)is a kind of phosphatase proteins mainly but not completely expressed in the cytoplasm of hematopoietic cells.It belongs to the inositol 5-phosphatase family and is an important negative regulator of phosphatidylinositol-3-kinase(PI3K)signal pathway.PI3K signal pathway has been proved to play a role in tumorigenesis and development.As a regulator of phosphoinositide signal pathway,SHIP1 plays an important role in tumorigenesis,development and immune regulation.The purpose of this review is to summarize the role of SHIP1 in tumorigenesis,development and immune regulation,in order to explore new ways of tumor treatment.

关 键 词：SH2区域的肌醇5′磷酸酶1 肿瘤 免疫调节 

分 类 号：R730[医药卫生—肿瘤]