眼表稳态失衡与组织重建策略  

Ocular surface homeostasis imbalance and tissue reconstruction strategies

作　　者：金梦怡 刘真[1] 曾百卉 康红花 石芮泽 郑岚 范凯 李程[1] JIN Mengyi;LIU Zhen;ZENG Baihui;KANG Honghua;SHI Ruize;ZHENG Lan;FAN Kai;LI Cheng(Fujian Provincial Key Laboratory of Ophthalmology and Visual Science,Eye Institute,Xiamen University,Xiamen 361102,China;Department of Ophthalmology,The First Affiliated Hospital of University of South China,Hengyang 421001,China;Department of Ophthalmology·Optometry Center,China-Japan Union Hospital of Jilin University,Changchun 130012,China)

机构地区：[1]厦门大学眼科研究所,福建省眼科与视觉科学重点实验室,福建厦门361102 [2]南华大学附属第一医院眼科,湖南衡阳421001 [3]吉林大学中日联谊医院眼科·视光中心,吉林长春130012

出　　处：《厦门大学学报（自然科学版）》2024年第5期867-882,共16页Journal of Xiamen University：Natural Science

摘　　要：[背景]眼表位于眼球的最外层,是一个精细且复杂的系统,包括角膜、结膜以及相关的眼睑和泪腺,在维持人类视觉功能方面起着至关重要的作用.随着眼表组织器官培养技术在眼科领域的快速发展,研究人员能够更全面地探索其在不同生理和病理状态下的复杂特性.[进展]环境污染、干燥应激等因素会对眼表组织构成威胁,导致稳态失衡和损伤.近几十年来针对环境污染对眼表组织影响的研究不断涌现,与此同时,眼表重建技术不断发展,如组织工程角膜、小分子化学药物应用,以及先进的眼表药物递送系统等.本文系统地梳理了眼表组织器官培养技术的最新进展、环境污染和干燥应激下眼表细胞的功能紊乱,以及多样化的眼表重建策略.[展望]未来持续深入研究眼表系统的稳态维持机制和疾病发生机制,探索更多有效的治疗方法和药物递送策略,将为眼科医生、研究人员及决策者提供更深入的参考和启示,推动眼表组织健康与治疗的进一步发展.[Background]The ocular surface is a morpho-functional unit comprising the major lacrimal glands,cornea,conjunctiva,tear film,immune cells and nerve fibers.These components work together to maintain homeostasis,which is essential for proper visual function.They form the first line of defense against environmental insults and are vital for the health and functionality of the eye.With the rapid development of ocular surface organ culture techniques in ophthalmology,researchers can now explore the complex characteristics of these tissues under various physiological and pathological states more deeply and comprehensively.Environmental pollution,such as exposure to particulate matter and chemicals,along with dry stress caused by reduced tear production or increased evaporation,poses significant threats to ocular surface tissues.These factors can lead to homeostasis imbalance,inflammation,and tissue damage,ultimately impairing visual function.Understanding these impacts is crucial for developing effective prevention and treatment strategies.[Progress]Despite numerous studies on the impact of environmental pollution on ocular surface tissues in recent decades,a comprehensive understanding of the damage mechanisms remains elusive.Research has shown that pollutants,such as particulate matter,chemicals,and allergens,can induce oxidative stress,inflammation,and cellular apoptosis in ocular surface cells.These pollutants can disrupt the tear film,cause damage to the epithelial cells,and impair the overall integrity of the ocular surface,leading to conditions such as dry eye syndrome and conjunctivitis.Additionally,dry stress,often exacerbated by environmental factors such as low humidity,high wind,and excessive screen time,can lead to similar detrimental effects.Dry stress reduces tear production and increases tear evaporation,resulting in tear film instability.This instability can cause microdamage to corneal and conjunctival epithelial cells,triggering inflammatory responses and further compromising ocular surface health.Th

关 键 词：眼表 器官培养 环境污染 小分子药物 药物递送 

分 类 号：R771[医药卫生—眼科]