卵巢癌神经调控的研究进展  

Advances in research on neuromodulation of ovarian cancer

作　　者：李凡舒 孙艳荣 张艳[2] 栾丽菊 张卫光[2] LI Fan-shu;SUN Yan-ong;ZHANG Yan;LUAN Liju;ZHANG Wei-guang(Grade 2020,Clinical Eight-Year,Peking University Health Science Center,Beijing 100083,China;Department of Human Anatomy and Embryology,Peking University School of Basic Medicine,Bejing 100083,China)

机构地区：[1]北京大学医学部,北京100083 [2]北京大学基础医学院人体解剖学与组织学胚胎学系,北京100083

出　　处：《解剖学报》2024年第5期647-653,共7页Acta Anatomica Sinica

摘　　要：卵巢癌是世界上最为常见的女性癌症之一。在过去的数十年中,已经有大量关于癌症发生与进展机制的研究,多种神经以及神经介质参与其中。神经支配在卵巢癌中也存在,并且对于卵巢癌而言,各种神经以及神经递质发挥着不同的作用,卵巢癌细胞的增殖、转移、凋亡以及肿瘤微环境的改变都与之相关。深入探讨和理解这些神经末梢在卵巢癌发展当中分别扮演了什么角色,是了解肿瘤进展机制的必要环节,对于后续针对肿瘤调控的研究具有重要作用。虽然糖皮质激素和交感神经释放的去甲肾上腺素能够促进卵巢癌的进展,但血清素可能会抑制癌细胞生长,同时,副交感神经和感觉神经也能够对卵巢肿瘤产生或正或负的影响。这些相关研究为肿瘤治疗方案提供了新的可能,或许通过较低价格的受体抑制剂或激动剂就能够缓解癌症的进展,有利于后续针对卵巢癌以及其他癌症相关治疗可行性的探索。我们通过本文综述了神经对卵巢癌发生、发展的调节作用,希望能够为卵巢癌临床诊疗提供新的思路。Ovarian cancer is one of the most common gynecologic cancers in the world.Over the past few decades,there has been considerable research reporting on the mechanisms of cancer development and progression,with multiple nerve as well as neurotransmitters involved.Nerve innervation is also found in ovarian cancer.And in ovarian cancer,various nerves and neurotransmitters play different roles.They are involved in ovarian cancer cells'proliferation metastasis,apoptosis and changes in the tumor microenvironment.Further understanding of the role of these nerve endings in the development of ovarian cancer is essential for understanding the mechanisms of cancer progression.This will be important for subsequent research focusing on tumor regulation.While glucocorticoids and sympathetic nerve-released norepinephrine are able to promote ovarian cancer progression,serotonin may inhibit cancer cell growth.Also,parasympathetic and sensory nerves are capable of having either a positive or negative effect on ovarian tumors.These relevant studies offer the possibility of new therapeutic options for oncology,it may be possible to mitigate the progression of cancer with inexpensive receptor inhibitors or agonists.This will facilitate the subsequent exploration of therapeutic possibilities forovarian cancer and other cancer-related treatments.In this review,we also present some insights into the role of the nervous system in the regulation of ovarian cancer,which we hope will provide new insights into the innervation and progression of ovarian cancer.

关 键 词：卵巢癌 慢性应激 神经浸润 神经递质 肿瘤微环境 

分 类 号：R737.31[医药卫生—肿瘤]