Unveiling ferroptosis as a promising therapeutic avenue for colorectal cancer and colitis treatment  

作　　者：Aaron T.Kaoy Christian V.Cabanlongy Kendra Padilla Xiang Xue 

机构地区：[1]Department of Biochemistry and Molecular Biology,University of New Mexico,Albuquerque,NM 87131,USA

出　　处：《Acta Pharmaceutica Sinica B》2024年第9期3785-3801,共17页药学学报（英文版）

基　　金：the NIGMS funded Academic Science Education and Research Training(ASERT,K12-GM088021)Program at the University of New Mexico Health Sciences Center;Xiang Xue received partial funding support from the National Institutes of Health(P20 GM130422);a Research Scholar Grant from the American Cancer Society(RSG-18-050-01-NEC);Environmental Health and Toxicology Pilot Awards from UNM Center for Native Environmental Health Equity Research(P50 MD015706);New Mexico Integrative Science Program Incorporating Research in Environmental Sciences(NM-INSPIRES,1P30ES032755);Xiang Xue also acknowledges funding support from a Research Program Support Pilot Project Award from UNM comprehensive cancer center(P30CA118100);the Cardiovascular and Metabolic Disease Research Program Pilot Project Grant from UNMHSC Office of Research Signature Programs。

摘　　要：Ferroptosis is a novel type of regulated cell death(RCD)involving iron accumulation and lipid peroxidation.Since its discovery in 2012,various studies have shown that ferroptosis is associated with the pathogenesis of various diseases.Ferroptotic cell death has also been linked to intestinal dysfunction but can act as either a positive or negative regulator of intestinal disease,depending on the cell type and disease context.The continued investigation of mechanisms underlying ferroptosis provides a wealth of potential for developing novel treatments.Considering the growing prevalence of intestinal diseases,particularly colorectal cancer(CRC)and inflammatory bowel disease(IBD),this review article focuses on potential therapeutics targeting the ferroptotic pathway in relation to CRC and IBD.

关 键 词：Ferroptosis Colorectal cancer Inflammatory bowel disease Cell death Molecular mechanisms Iron metabolism Drug therapies Targeted therapeutics 

分 类 号：R735.34[医药卫生—肿瘤]