基于网络药理学的肉豆蔻抗肿瘤活性成分及作用机制研究  

Study on the anti-tumor active ingredients and mechanism of nutmeg based on network pharmacology

作　　者：阿提合尼木·艾买提 加勒哈斯别克·塞力克 梁永红[1] 孟新源[1] ATIHENIMU Aimaiti;JIALEHASIBIEKE Sailike;LIANG Yonghong;MENG Xinyuan(Department of Pharmacy,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院药学部,新疆乌鲁木齐830011

出　　处：《中国民族医药杂志》2024年第8期46-50,共5页Journal of Medicine and Pharmacy of Chinese Minorities

摘　　要：目的:基于网络药理学的方法,筛选肉豆蔻的有效活性成分,并预测其潜在的抗肿瘤靶点及筛选潜在抗肿瘤靶点的相关通路,探讨其抗肿瘤的作用机制。方法:通过查阅大量国内外文献,整理并获得肉豆蔻活性成分,利用多种数据库预测成分相关靶点,并与肿瘤靶点进行映射,得到活性成分的潜在抗肿瘤靶点,运用Cystoscope 3.6.1软件构建“化合物-基因”网络图筛选关键化合物和关键靶点,最后进行通路富集分析。结果:从肉豆蔻中一共筛选出有效活性成分19种,通过网络建模共筛选出与肿瘤相关的70个高频作用靶点和13条信号通路。富集分析结果显示,这些作用通路可能是肉豆蔻抗肿瘤的活性依据。结论:通过这次虚拟网络筛选,肉豆蔻通过多成分、多靶点和多途径的抗肿瘤方式发挥其抗肿瘤作用,这可为后续深入研究肉豆蔻抗肿瘤机制提供新的思路和线索。Objective: Based on the method of network pharmacology, to screen the active ingredients of nutmeg, predict its potential anti-tumor targets and screen the related pathways of potential anti-tumor targets, and explore its anti-tumor mechanism. Methods: By consulting a large number of domestic and foreign literatures, sorting out and obtaining the active ingredients of nutmeg, using a variety of databases to predict the relevant targets of the ingredients, and mapping with tumor targets, the potential anti-tumor targets of the active ingredients were obtained. The "compound-gene" network map was constructed with Cystoscope 3.6.1 software to screen key compounds and key targets. Finally, pathway enrichment analysis was performed. Results: A total of 19 active ingredients were screened from nutmeg, and 70 high-frequency targets and 13 signaling pathways related to tumor were screened through network modeling. The results of enrichment analysis showed that these pathways may be the basis for the anti-tumor activity of nutmeg. Conclusion: Through this virtual network screening, nutmeg exerts its antitumor effect through multi-component, multi-target and multi-pathway anti-tumor mode, which can provide new ideas and clues for further research on the anti-tumor mechanism of nutmeg.

关 键 词：肉豆蔻 网络药理学 肿瘤 

分 类 号：R284[医药卫生—中药学]