浙江省肿瘤登记地区2008—2019年胃癌5年生存率分析  

Five-year survival analysis of gastric cancer from population-based cancer registration data in Zhejiang province,China

作　　者：李辉章[1] 朱洪挺 陈瑶瑶 郑荣寿 靳光付 杜灵彬[1] 程向东[5] Li Huizhang;Zhu Hongting;Chen Yaoyao;Zheng Rongshou;Jin Guangfu;Du Lingbin;Cheng Xiangdong(Department of Cancer Prevention,Zhejiang Cancer Hospital(Zhejiang Cancer Center)/Zhejiang Provincial Office for Cancer Prevention and Control,Hangzhou 310022,China;Department of Chronic non-communicable Disease Control and Prevention,Yongkang Center for Disease Control and Prevention,Yongkang 321300,China;Office for Cancer Registry,National Cancer Center,Beijing 100021,China;Department of Epidemiology,School of Public Health,Nanjing Medical University,Nanjing 211166,China;Department of Gastric surgery,Zhejiang Cancer Hospital(Zhejiang Cancer Center)/Key Laboratory of Prevention,Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province,Hangzhou 310022,China)

机构地区：[1]浙江省肿瘤医院(浙江省癌症中心)肿瘤防治科,浙江省肿瘤防治办公室,杭州310022 [2]永康市疾病预防控制中心慢性非传染性疾病防制科,永康321300 [3]国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室,北京100021 [4]南京医科大学公共卫生学院流行病学系,南京211166 [5]浙江省肿瘤医院(浙江省癌症中心)胃外科,浙江省上消化道肿瘤防控与诊治重点实验室,杭州310022

出　　处：《中华肿瘤杂志》2024年第9期862-870,共9页Chinese Journal of Oncology

基　　金：国家重点研发计划(2021YFA0910100)。

摘　　要：目的分析以人群肿瘤登记为基础的浙江省胃癌5年生存率流行特征。方法收集浙江省22个国家级肿瘤登记地区2008—2019年胃癌病例随访数据,分为2008—2011年、2012—2015年和2016—2019年3个诊断时期,计算各时期胃癌的5年观察生存率、相对生存率及年龄标化相对生存率(ARSR),分析各时期胃癌生存率的人口学特征分布(包括性别、城乡、年龄和职业)和临床特征分布(包括最高诊断机构、亚部位、病理类型和分化程度)。结果纳入分析浙江省肿瘤登记地区2008—2019年胃癌新发病例51663例,2008—2011年、2012—2015年和2016—2019年胃癌ARSR呈上升趋势,分别为39.2%、41.3%和44.7%。2016—2019年,不同性别、城乡ARSR相近(男性44.4%,女性45.7%;城市地区44.9%,农村地区44.2%);不同职业人群中,商业、服务业人员ARSR最高(55.3%),农、林、牧、渔、水利业生产人员和家务人员较低(分别为41.5%和43.2%)。最高诊断机构为省级医院的胃癌生存率(47.0%)高于地市级(43.4%)和县区级(43.6%)。胃小弯(59.7%)、幽门(50.4%)、胃窦(49.3%)和胃大弯(48.7%)亚部位的胃癌ARSR相对较高,贲门癌ARSR最低(38.9%)。主要病理学类型中,腺癌(未特指)ARSR为48.1%,黏液腺癌为41.3%,印戒细胞癌为39.4%,鳞癌为33.4%。高分化、中分化、低分化和未分化的胃癌ARSR依次为80.6%、57.9%、43.2%和36.8%。结论浙江省胃癌5年生存率较高,且呈上升趋势,不同性别、城乡生存率相近,不同职业人群、最高诊断机构、肿瘤亚部位、病理学类型和分化程度的胃癌患者生存率存在明显差异。Objective To analyze epidemiology of gastric cancer five-year survival distribution in Zhejiang population-based cancer registration.Methods The follow-up data of registrated gastric cancer cases diagnosed from 2008 to 2019 in 22 national cancer registry areas of Zhejiang Province were collected and divided into three diagnostic periods:2008-2011,2012-2015 and 2016-2019 to calculate five-year observed survival rates(OSRs),five-year relative survival rates(RSRs)and five-year age-standardized relative survival rates(ARSRs).The distribution of population characteristics(including gender,urban/rural,age group and occupation)and clinical characteristics(including the highest diagnostic institution,sub-site,pathological type and degree of differentiation)of gastric cancer survival rates in each period were analysed.Results 51663 new cases of gastric cancer in 2008-2019 in the cancer registration area of Zhejiang Province were included in the analysis,and the ARSR of gastric cancer in 2008-2011,2012-2015 and 2016-2019 showed an increasing trend(39.2%,41.3%and 44.7%,respectively).In 2016-2019,the ARSR was similar across gender and urban and rural areas(44.4%for men and 45.7%for women;44.9%in urban areas and 44.2%in rural areas);Among people with different occupations,the ARSR was highest among business and service workers(55.3%),the agriculture,forestry,animal husbandry and fisheries,water conservancy production workers and domestic workers were lower(41.5%and 43.2%,respectively).The highest diagnostic institution was the provincial hospital with a higher gastric cancer survival rate(47.0%)than the municipal(43.4%)and district(43.6%)levels.The ARSR for gastric cancer was relatively high in the lesser curvature(59.7%),pylorus(50.4%),antrum(49.3%),and greater curvature(48.7%),and lowest in cardia(38.9%).Among the major pathological types,adenocarcinoma(NOS)had an ARSR of 48.1%,mucinous adenocarcinoma 41.3%,imprinted cell carcinoma 39.4%,and squamous carcinoma 33.4%.The ARSR for highly differentiated,moderately differentiat

关 键 词：胃肿瘤 人群肿瘤登记 生存率 趋势 

分 类 号：R735.2[医药卫生—肿瘤]