中青年无症状性脑梗死患者颈动脉硬化发生相关危险因素分析  

Analysis of Risk Factors for Carotid Arteriosclerosis in Young and Middle-aged Patients with Silent Brain Infarction

作　　者：张微 赵慧宇 马熙岳[1] ZHANG Wei;ZHAO Huiyu;MA Xiyue(Harbin 242 Hospital,Heilongjiang Province)

机构地区：[1]哈尔滨二四二医院,黑龙江哈尔滨150066

出　　处：《航空航天医学杂志》2024年第9期1025-1028,共4页Journal of Aerospace medicine

基　　金：黑龙江卫健委科研基金项目(20220303070635)。

摘　　要：目的 卒中是我国第三位死亡原因,致残率高,中青年无症状性脑梗死虽暂无明显神经缺损症状,但潜在危害高。目前对于中青年人群SBI的研究尚不完善,需进一步探索中青年无症状性脑梗死患者颈动脉硬化产生的相关危险因素。方法 回顾性分析91例中青年SBI患者的临床资料,根据颈动脉超声是否存在颈动脉硬化分为颈动脉硬化组及对照组。收集患者临床资料包括年龄、性别、实验室指标(高密度脂蛋、总胆固醇、甘油三酯、低密度脂蛋白、糖化血红蛋白、同型半胱氨酸、尿酸、空腹血糖)等。以颈动脉硬化为因变量,以上述单因素分析差异有统计学意义的项目为自变量进行危险因素多因素Logistic回归分析。结果 颈动脉硬化组46例,对照组45例。颈动脉硬化组平均年龄54(50~58)岁,对照组平均年龄53(47.5~56.5)岁,两组年龄及性别差异无统计学意义。颈动脉硬化组总胆固醇、低密度脂蛋白高于对照组,差异具有统计学意义(P<0.05),总胆固醇对中青年SBI颈动脉硬化发生影响有统计学意义(OR=4.492,OR95%CI:0.078-0.0.634,P<0.05),总胆固醇为中青年SBI颈动脉硬化发生的促进因素。结论 总胆固醇为中青年SBI颈动脉硬化发生的促进因素。Objective Stroke is the third cause of death in China,with high disability rate.Although young and middle-aged people with silent brain infarction has no obvious neurological defects,the potential harm is high.At present,the study of SBI in young and middle-aged population is not perfect,requiring further exploration of the related risk factors of carotid arteriosclerosis in young and middle-aged patients with asymptomatic cerebral infarction.Methods The clinical data of 91 young and middle-aged patients with SBI were divided into carotid arteriosclerosis group and control group according to the presence of carotid artery ultrasound.Clinical data of patients including age,sex,laboratory indicators(high-density fat egg,total cholesterol,triglycerides,low-density lipoprotein,glycated hemoglobin,homocysteine,uric acid,fasting blood glucose),etc.Multivariate Logistic regression analysis of risk factors was performed with carotid stiffness as dependent variable and items with statistically significant differences from the above univariate analysis as independent variables.Results 46 patients in the carotid arteriosclerosis group and 45 in the control group.The age of the carotid arteriosclerosis group was 54(50~58)years,and the mean age of the control group was 53(47.5~56.5)years.There was no significant difference in age and sex between the two groups.Total cholesterol and LDL in the carotid arteriosclerosis group were higher than that in the control group,which was statistically significant(P<0.05),total cholesterol affected the occurrence of SBI in young and middle-aged people(OR=4.492,OR95%CI:0.078-0.0.634,P<0.05).Cholesterol total was the promoting factor of SBI in young and middle-aged people.Conclusions Total cholesterol is a promoting factor of SBI in young and middle-aged patients.

关 键 词：无症状性脑梗死 中青年 颈动脉硬化 相关因素分析 

分 类 号：R741[医药卫生—神经病学与精神病学]