高频彩超联合血清LAG-3 FGFR-4对甲状腺癌的诊断价值  

Diagnostic Value of High-Frequency Ultrasound Combined with Serum LAG-3 and FGFR-4 in Thyroid Cancer

作　　者：赵新燕 王军[1] ZHAO Xinyan;WANG Jun(Taiyuan Central Hospital,Shanxi Taiyuan 030009,China)

机构地区：[1]山西省太原市中心医院超声科,山西太原030009

出　　处：《河北医学》2024年第9期1539-1545,共7页Hebei Medicine

基　　金：山西省卫生健康委科研课题,(编号:2020109)。

摘　　要：目的:探讨血清淋巴细胞活化基因-3(LAG-3)、成纤维生长因子受体4(FGFR-4)在甲状腺癌(TC)中的表达,并联合高频彩超对TC的诊断价值。方法:选取2020年12月至2023年12月期间在本院收治的203例甲状腺病变患者为研究对象,根据病理学检查结果将其分为TC患者作为TC组(n=108),甲状腺良性病变患者为非TC组(n=95)。采用ELISA法测定血清LAG-3、FGFR-4表达水平;ROC曲线分析血清LAG-3、FGFR-4对TC的诊断效能;四格表法分析高频彩超联合血清LAG-3、FGFR-4水平对TC的诊断效能。结果:与甲状腺未分化癌相比,甲状腺乳头状癌、甲状腺滤泡状癌、甲状腺髓样癌血清LAG-3水平显著升高,血清FGFR-4水平显著降低(P<0.05)。与非TC组相比,TC组血清LAG-3水平显著降低,血清FGFR-4水平显著升高(P<0.05)。TC组PSV、RI水平显著高于非TC组(P<0.05)。高频彩超联合血清LAG-3、FGFR-4诊断TC的准确率为86.70%,敏感度为96.30%,特异度为75.79%。其中,三项联合诊断的敏感度高于高频彩超、血清LAG-3、FGFR-4单独诊断(P<0.05)。结论:TC患者的血清LAG-3水平显著降低,血清FGFR-4水平显著升高,高频彩超联合血清LAG-3、FGFR-4对TC具有更高的诊断效能。Objective:To investigate the expression of serum lymphocyte activation gene 3(LAG-3)and fibroblast growth factor receptor 4(FGFR-4)in thyroid cancer(TC),and the diagnostic value of them combined with high-frequency ultrasound for TC.Methods:A total of 203 patients with thyroid lesions admitted to our hospital from December 2020 to December 2023 were enrolled as the study subjects.Based on the pathological examination results,they were separated into TC patients as the TC group(n=108)and benign thyroid lesions patients as the non-TC group(n=95).ELISA method was applied to determine the expression levels of serum LAG-3 and FGFR-4.ROC curve was plotted to analyze the diagnostic efficacy of serum LAG-3 and FGFR-4 for TC.Four grid table method was applied to analyze the diagnostic efficacy of high-frequency ultrasound combined with serum LAG-3 and FGFR-4 levels for TC.Results:Compared with undifferentiated thyroid carcinoma,the serum LAG-3 level of papillary,follicular,and medullary thyroid carcinoma was significantly increased,and the serum FGFR-4 level was significantly decreased(P<0.05).Compared with the non-TC group,the serum LAG-3 level in the TC group was reduced,and the serum FGFR-4 level was increased(P<0.05).The levels of PSV and RI in the TC group were higher than those in the non-TC group(P<0.05).The accuracy,sensitivity,and specificity of high-frequency ultrasound combined with serum LAG-3 and FGFR-4 in diagnosing TC were 86.70%,96.30%,and 75.79%,respectively.Among them,the sensitivity of the three combined diagnoses was higher than that of high-frequency ultrasound,serum LAG-3,and FGFR-4 individual diagnoses(P<0.05).Conclusion:The serum LAG-3 level in TC patients is reduced,while the serum FGFR-4 level is increased.High-frequency ultrasound combined with serum LAG-3 and FGFR-4 has higher diagnostic efficacy for TC.

关 键 词：淋巴细胞活化基因-3 成纤维生长因子受体4 高频彩超 甲状腺癌 诊断 

分 类 号：R736.1[医药卫生—肿瘤]