高压氧联合丁苯酞治疗脑梗死患者的效果  

Effect of Hyperbaric Oxygen Combined with Butylphthalide in the Treatment of Patients with Cerebral Infarction

作　　者：黄雪娇 黄苡苹[1] HUANG Xuejiao;HUANG Yiping(Putian University Affiliated Hospital,Putian 351100,China;不详)

机构地区：[1]莆田学院附属医院,福建莆田351100

出　　处：《中外医学研究》2024年第26期22-25,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨高压氧联合丁苯酞治疗脑梗死患者的效果。方法:选取2020年1月—2022年12月莆田学院附属医院收治的90例脑梗死患者作为研究对象,按照随机抽签法将患者分为观察组与对照组,各45例。两组均给予常规治疗,其中对照组加用丁苯酞,观察组在对照组基础上联用高压氧,比较两组临床疗效、神经功能缺损情况、脑血流动力学、生活质量。结果:观察组治疗总有效率为97.78%,高于对照组的84.44%,差异有统计学意义(P<0.05);观察组治疗10 d、20 d美国国立卫生研究院脑卒中量表(NIHSS)评分低于对照组,差异有统计学意义(P<0.05);治疗后,两组脑平均血流速度及生理、心理、社会、环境评分高于治疗前,且观察组治疗后更高,两组治疗后血细胞比容、纤维蛋白原低于治疗前,且观察组治疗后更低,差异有统计学意义(P<0.05)。结论:高压氧联合丁苯酞治疗脑梗死效果佳,能改善神经功能缺损程度和脑血流动力学,提高生活质量。Objective:To investigate the effect of hyperbaric oxygen combined with Butylphthalide in the treatment of patients with cerebral infarction.Method:Ninety patients with cerebral infarction who admitted to Putian University Affiliated Hospital from January 2020 to December 2022 were selected as the study objects,and they were randomly divided into the observation group and the control group,with 45 cases in each group.All patients were given routine treatment,the control group was treated with Butylphthalide,and the observation group was treated with hyperbaric oxygen on the basis of the control group.The clinical efficacy,neurological deficit,cerebral hemodynamics and quality of life were compared between two groups.Result:The total effective rate of the observation group was 97.78%,which was higher than 84.44%of the control group,and the difference was statistically significant(P<0.05);the National Institutes of Health stroke scale(NIHSS)scores of the observation group at 10 d,20 d of treatment were lower than those of the control group,and the differences were statistically significant(P<0.05);after treatment,the average cerebral blood flow velocity and physiological,psychological,social and environmental scores of two groups were higher than those before treatment,and those in the observation group were higher after treatment,the hematocrit and fibrinogen of two groups after treatment were lower than those before treatment,and those in the observation group were lower after treatment,the differences were statistically significant(P<0.05).Conclusion:Hyperbaric oxygen combined with Butylphthalide in the treatment of cerebral infarction has a significant therapeutic effect,which can improve the degree of neurological deficits and cerebral hemodynamics,and enhance quality of life.

关 键 词：脑梗死 丁苯酞 高压氧 神经功能 生活质量 

分 类 号：R743.33[医药卫生—神经病学与精神病学]