颈动脉超声联合颈动脉超声造影、血清脂联素及超敏C反应蛋白检测在动脉粥样硬化脑梗死中的应用价值分析  

Analysis of the value of carotid ultrasound and contrast-enhanced ultrasound combined with serum adiponectin and hypersensitive C-reactive protein in atherosclerotic cerebral infarction

作　　者：徐迎春 XU Ying-chun(Ultrasound Department,Chengwu County People's Hospital,Heze 274200,China)

机构地区：[1]成武县人民医院超声科,274200

出　　处：《中国实用医药》2024年第19期65-68,共4页China Practical Medicine

摘　　要：目的 分析动脉粥样硬化脑梗死患者采用颈动脉超声联合颈动脉超声造影、血清脂联素及超敏C反应蛋白检测的临床应用价值。方法 选取66例动脉粥样硬化脑梗死患者作为研究组,另选取66例健康体检者作为常规组。对两组进行颈动脉超声、颈动脉超声造影检查,掌握动脉粥样硬化斑块类型和分级;分别采用酶联免疫吸附法、免疫比浊法对两组血清脂联素、超敏C反应蛋白水平进行检测。比较常规组与研究组血清脂联素、超敏C反应蛋白水平;分析颈动脉超声及超声造影的检测结果;比较不同斑块类型患者、软斑块内新生血管不同分级患者的血清脂联素、超敏C反应蛋白水平。结果 研究组血清脂联素水平(472.76±44.78)μg/ml低于常规组的(750.59±30.41)μg/ml,超敏C反应蛋白水平(10.93±2.87)mg/L高于常规组的(5.01±1.08)mg/L(P<0.05)。颈动脉超声检测结果显示:研究组患者中46例检测出斑块,检出率为69.70%(46/66);其中硬斑块30例,软斑块16例。硬斑块患者血清脂联素水平(580.85±132.69)μg/ml高于软斑块患者的(394.01±115.24)μg/ml,血清超敏C反应蛋白水平(11.13±2.81)mg/L低于软斑块患者的(13.18±2.67)mg/L(P<0.05)。颈动脉超声造影对16例软斑块患者进行进一步超声造影增强检测,结果显示:新生血管分级1、2级斑块共计6例, 3、4级斑块共计10例。3、4级斑块患者血清脂联素水平(318.87±112.04)μg/ml低于1、2级患者的(519.46±118.48)μg/ml,超敏C反应蛋白水平(14.34±2.85)mg/L高于1、2级患者的(11.00±1.56)mg/L(P<0.05)。结论 颈动脉粥样硬化斑块类型与脑梗死发生关系密切,血清脂联素、超敏C反应蛋白水平与脑梗死及斑块的稳定性密切相关;颈动脉超声及超声造影结合血清脂联素与超敏C反应蛋白水平检测有助于评估脑梗死的风险及指导临床防治。Objective To analyze the clinical value of carotid ultrasound and contrast-enhanced ultrasound combined with adiponectin and hypersensitive C-reactive protein in atherosclerotic cerebral infarction.Methods 66 patients with atherosclerotic cerebral infarction were selected as the study group,and another 66 healthy subjects were selected as the conventional group.Carotid ultrasound and contrast-enhanced ultrasound were performed in the two groups to determine the type and grade of atherosclerotic plaque.Enzyme-linked immunosorbent assay and immunoturbidimetric assay were used to detect serum adiponectin and hypersensitive C-reactive protein.The serum adiponectin and hypersensitive C-reactive protein levels were compared between the conventional group and the study group,and the detection results of carotid ultrasound and contrast-enhanced ultrasound were analyzed.The serum adiponectin and hypersensitive C-reactive protein levels of patients with different plaque types and patients with different levels of neovascularization in soft plaques were compared.Results The study group had lower serum lipocalin level of(472.76±44.78)μg/ml than(750.59±30.41)μg/ml in the conventional group,and higher hypersensitive C-reactive protein level of(10.93±2.87)mg/L than(5.01±1.08)mg/L in the conventional group(P<0.05).Regarding the results of carotid ultrasound,plaque was detected in 46 patients in the study group,with a detection rate of 69.70%(46/66),in which there were 30 cases of hard plaques and 16 cases of soft plaques.In patients with hard plaques,the serum lipocalin level of(580.85±132.69)μg/ml was higher than(394.01±115.24)μg/ml in patients with soft plaques,and the serum ultrasensitive C-reactive protein level of(11.13±2.81)mg/L was lower than(13.18±2.67)mg/L in patients with soft plaques(P<0.05).As for the results of carotid ultrasound,further contrast-enhanced ultrasound was performed in 16 patients with soft plaques to grade the neovascularization within the plaque,with a total of 6 cases of grade 1 and grad

关 键 词：颈动脉超声 颈动脉超声造影 血清脂联素 超敏C反应蛋白 动脉粥样硬化脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R445.1[医药卫生—临床医学]