盆腔“卷地毯”式CRS在晚期上皮性卵巢癌手术治疗中的临床效果分析  

The clinical effect of pelvic peritonectomy in the surgical treatment of advanced epithelial ovarian cancer

作　　者：孟龄婷 杨斌 赵西侠 许昭 雷磊 MENG Lingting;YANG Bin;ZHAO Xixia;XU Zhao;LEI Lei(Shaanxi Provincial Tumor Hospital,Shaanxi Xi'an 710061,China)

机构地区：[1]陕西省肿瘤医院,陕西西安710061

出　　处：《现代肿瘤医学》2024年第20期3910-3915,共6页Journal of Modern Oncology

摘　　要：目的:分析盆腔腹膜切除术(pelvic peritonectomy,PP)在晚期上皮性卵巢癌(epithelial ovarian cancer,EOC)手术治疗中的临床效果。方法:回顾性分析2017年1月至2020年1月于我院行包含PP的卵巢癌肿瘤细胞减灭术(cytoreductive surgery,CRS)的EOC患者(PP-CRS组,即盆腔“卷地毯”式CRS组)的相关临床资料,共45例。选取同期行传统CRS手术的EOC患者45例(传统CRS组)作为对照组。比较两组患者的临床资料、手术相关资料,评价盆腔“卷地毯”式CRS在晚期EOC手术治疗中的临床效果。结果:PP-CRS组的手术满意度CC评分(complete cytoreduction score)显著高于传统CRS组(P<0.05)。PP-CRS组较传统CRS组减少了一线化疗疗程数(P<0.05)。两组患者在年龄、体质量指数(BMI)、病理类型、病理分级、病理分期、新辅助化疗比例、ECOG评分(Eastern Cooperative Oncology Group performance status)、3年无进展生存率(progression-free survival,PFS)、手术时间、出血量、住院时间、术后首次化疗时间及手术并发症方面差异无统计学意义(P>0.05)。结论:相比传统CRS手术,PP-CRS手术满意度高、可减少一线总化疗疗程数、且手术难度较低、术后并发症发生率较低。手术治疗采用PP-CRS具有临床意义,值得在临床工作中进行推广。Objective:To analyze the clinical efficacy of pelvic peritonectomy(PP)in the surgery of advanced epithelial ovarian cancer(EOC).Methods:The clinical data of 45 EOC patients(PP-CRS group)who underwent cytoreductive surgery(CRS)with PP in our hospital from January 2017 to January 2020 were retrospectively analyzed.Meanwhile,45 EOC patients(traditional CRS group)who underwent traditional CRS during the same period were selected as the control group.The clinical pathological data and surgery-related data of the two groups were compared to evaluate the clinical efficacy of PP in the surgery of advanced EOC.Results:The complete cytoreduction score(CC score)of the PP-CRS group was significantly higher than that of the traditional CRS group(P<0.05).There was also a significant difference in the number of first-line chemotherapy cycles between the two groups,with the PP-CRS group having fewer chemotherapy cycles than the traditional CRS group(P<0.05).There was no significant difference between the two groups in terms of age,body mass index(BMI),pathological type,pathological grade,pathological stage,neoadjuvant chemotherapy ratio,Eastern Cooperative Oncology Group performance status(ECOG score),3-year progression-free survival(PFS),operation time,blood loss,hospital stay,time to first postoperative chemotherapy and surgery complications(P>0.05).Conclusion:PP-CRS is relatively simple to operate and has a low incidence of postoperative complications,which also can improve the surgical satisfaction and reduce the total number of first-line chemotherapy cycles.Therefore,PP-CRS has clinical significance for the surgical treatmentof advanced EOC and is worthy of promotion in clinical practice.

关 键 词：全盆腔腹膜切除术 晚期上皮性卵巢癌 手术步骤 手术满意度 化疗疗程数 术后并发症 

分 类 号：R737.31[医药卫生—肿瘤]