空间生物学和肿瘤研究  

Spatial biology and cancer research

作　　者：岳红云 张百红 YUE Hongyun;ZHANG Baihong(Department of Ophthalmology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Gansu Lanzhou 730050,China;Department of Oncology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Gansu Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院眼科,甘肃兰州730050 [2]中国人民解放军联勤保障部队第九四〇医院肿瘤科,甘肃兰州730050

出　　处：《现代肿瘤医学》2024年第20期3987-3990,共4页Journal of Modern Oncology

基　　金：甘肃省自然科学基金项目(编号:22JR5RA007);联勤保障部队第九四〇医院项目(编号:20yjky019)。

摘　　要：空间生物学研究组织的空间结构和细胞的相互作用。空间生物学应用空间多组学联合图像分析和深度学习定位肿瘤细胞和亚细胞、理解肿瘤克隆进化、阐释肿瘤细胞与微环境之间作用和预测肿瘤治疗反应,这将进一步推动肿瘤精准治疗。Spatial biology maps tissue architecture and interrogates cell to cell interactions.Spatial biology can define the identity of cancer cells and subcellular fraction,map tumor clones evolution,reveal the interactions between tumor cells and microenvironment,and predict therapeutic responses using spatial omics and deep learning within their spatial context.Spatial biology will further improve precision treatment of human cancers.

关 键 词：肿瘤 空间生物学 空间组学 肿瘤研究 

分 类 号：R730.5[医药卫生—肿瘤]