ALKBH5及其在肿瘤发生发展中作用的研究进展  

Research progress on ALKBH5 and its role in the occurrence and development of tumors

作　　者：尹峰 史振宇 汤雨盈 王雨婷 刘慧 谈晶 丁昊 陈文刚 程峰 YIN Feng;SHI Zhenyu;TANG Yuying;WANG Yuting;LIU Hui;TAN Jing;DING Hao;CHEN Wengang;CHENG Feng(Department of Pharmacy,the Second Affiliated Hospital of Wannan Medical College,Anhui Wuhu 241000,China;School of Clinical Medicine,Wannan Medical College,Anhui Wuhu 241002,China;School of Clinical Medicine,Anhui Medical University,Anhui Hefei 230031,China)

机构地区：[1]皖南医学院第二附属医院药剂科,安徽芜湖241000 [2]皖南医学院临床医学院,安徽芜湖241002 [3]安徽医科大学临床医学院,安徽合肥230031

出　　处：《现代肿瘤医学》2024年第20期3999-4004,共6页Journal of Modern Oncology

基　　金：国家级大学生创新创业训练计划项目(编号:202110368032);安徽省卫生健康委科研项目(编号:AHWJ2022a028);安徽省大学生创新创业训练计划项目(编号:202210368125);安徽高校自然科学研究项目(编号:KJ2021A0831);皖南医学院第二附属医院“登峰计划”人才科研项目(编号:DFJH2022008)。

摘　　要：ALKBH5(AlkB homolog 5)是m 6A去甲基转移酶蛋白,能去除RNA上的腺嘌呤(A)第6号位氮原子的甲基化。随着科技的进展,越来越多的研究表明,ALKBH5介导的m 6A去甲基化修饰在肿瘤的发生发展中起着重要作用。该文主要介绍了ALKBH5的结构,与其作为癌基因与抑癌基因在各种肿瘤发生发展中所起到的作用,以及ALKBH5表达及功能的调控,旨在为基础及临床医学中对m 6A修饰的研究提供新的研究思路和治疗靶点。AlkB homolog 5(ALKBH5)is a m 6A demethyltransferase protein,which removes the methylation of the nitrogen atom at the 6th position of adenine(A)on RNA.With the development of science and technology,more and more studies showed that ALKBH5 mediated m 6A demethylation plays an important role in the tumorigenesis and development.This review focuses on the structure of ALKBH5,its role as an oncogene and tumor suppressor gene in tumorigenesis and development,and the regulation of ALKBH5 expression and function.The aim of this study is to provide new research ideas and therapeutic targets for m 6A modification in basic and clinical medicine.

关 键 词：AlkB同源蛋白5 N 6-甲基腺苷 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]