肠道屏障与肠道菌群在溃疡性结肠炎中的研究进展  

Research progress of intestinal barrier and gut microbiota in ulcerative colitis

作　　者：叶梦玲 刘阳[1] 汤磊磊 蒋国军 YE Mengling;LIU Yang;TANG Leilei;JIANG Guojun(School of Pharmacy,Hangzhou Normal University,Hangzhou 311121,Zhejiang,China;Department of Pharmacy,Affiliated Xiaoshan Hospital,Hangzhou Normal University,Hangzhou 311200,Zhejiang,China)

机构地区：[1]杭州师范大学药学院,浙江杭州311121 [2]杭州师范大学附属萧山医院药剂科,浙江杭州311200

出　　处：《微生物学通报》2024年第9期3384-3397,共14页Microbiology China

基　　金：杭州生物医药和健康产业发展扶持科技专项(2022WJC139)。

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种发病机制不明的炎症性肠道疾病,发病率不断上升。完整的肠道屏障对维持肠道稳态和防治疾病至关重要。肠道菌群在构成肠道屏障、增强肠黏膜免疫反应和维持肠道内环境方面具有重要作用。肠道内菌群失衡会导致肠道屏障损伤,而肠道屏障损伤和肠道菌群失衡参与UC的发生发展。近年来,关于UC的研究越来越多地从肠道屏障和调节肠道菌群方面进行。本文就肠道屏障的组成及肠道菌群在UC中的作用进行综述,为该领域今后的研究提供理论依据。Ulcerative colitis(UC)is an inflammatory bowel disease with unknown pathogenesis and increasing incidence.An intact intestinal barrier is essential for maintaining intestinal homeostasis and preventing diseases.The gut microbiota plays a crucial role in constituting the intestinal barrier,enhancing the immune response of the intestinal mucosa,and maintaining the intestinal environment.The gut microbiota imbalance can lead to intestinal barrier damage,and both intestinal barrier damage and gut microbiota imbalance are involved in the development of UC.In recent years,increasing studies of UC focused on the intestinal barrier and regulation of gut microbiota have been carried out.This article reviews the components of the intestinal barrier and the role of gut microbiota in UC,aiming to provide a theoretical basis for the future research in this field.

关 键 词：溃疡性结肠炎 肠道屏障 肠道菌群 微生态制剂 

分 类 号：R574.62[医药卫生—消化系统]