幽门螺杆菌感染抗体分型与胃黏膜炎性病变程度及黏膜组织学变化间的相关性  

Correlation between Helicobacter pylori infection antibody typing and the severity of gastric mucosal inflammatorylesions and mucosal histological changes

作　　者：沈华娟 庄剑波 刘春[1] Shen Huajuan;Zhuang Jianbo;Liu Chun(Department of Gastroenterology Suzhou High-tech Zone Peeople'sHospital,Suzhou 215000,China)

机构地区：[1]苏州高新区人民医院消化内科,苏州市215000

出　　处：《中华实验和临床感染病杂志（电子版）》2024年第3期156-162,共7页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：苏州市科技局科技发展计划一指导性(No.SKJYD2021062)。

摘　　要：目的探讨幽门螺杆菌感染抗体分型与胃黏膜炎性病变程度及组织学变化的相关性。方法收集2019年9月至2022年9月于苏州高新区人民医院行胃镜检查、组织活检和幽门螺杆菌感染抗体检测的162例患者的临床资料。免疫印迹法检测血清幽门螺杆菌感染抗体表达及分型,病理检查胃黏膜炎性病变程度和组织学变化;比较不同性别、年龄患者幽门螺杆菌感染抗体分型;比较不同幽门螺杆菌感染抗体分型患者胃黏膜炎性病变程度及组织学变化;Spearman相关分析幽门螺杆菌感染抗体分型、胃黏膜炎性病变程度及组织学变化间的相关性。结果不同性别患者幽门螺杆菌感染抗体分型为Ⅰ型(χ^(2)=0.206、P=0.650)、Ⅱ型(χ^(2)=0.523、P=0.469)及总阳性率(χ^(2)=0.956、P=0.328)差异均无统计学意义:不同年龄患者1型幽门螺杆菌感染阳性率(χ^(2)=12.988、P=0.002)及总阳性率(χ^(2)=7.694、P=0.021)差异具有统计学意义;不同胃黏膜炎性病变程度患者间幽门螺杆菌感染抗体分型为阴性比例(χ^(2)=15.589、P<0.001)和Ⅰ型比例(P<0.001)差异具有统计学意义;Ⅰ型幽门螺杆菌感染的毒素相关基因A(CagA)阳性、空泡毒素基因A(VacA)阳性、CagA+VacA阳性率差异均无统计学意义(Fisher’s确切概率法:P=0.638、0.773、0.311);不同组织学病理结果患者间幽门螺杆菌感染抗体分型为阴性比例(χ^(2)=11.441、P=0.003)和Ⅰ型比例(χ^(2)=17.765、P<0.001)差异具有统计学意义,CagA、VacA、CagA+VacA差异均无统计学意义(Fisher’s确切概率法:P=0.242、0.288、0.786);幽门螺杆菌感染抗体分型、胃黏膜炎性病变程度及组织学变化间均呈显著正相关(r=0.411、0.322、0.808,均P<0.001)。结论幽门螺杆菌感染血清抗体分型与胃黏膜炎性病变程度及组织学变化间具有显著相关性,Ⅱ型幽门螺杆菌感染者中胃黏膜炎性病变程度为重度、组织学变化为胃癌的患者更多,幽门螺杆�Objective To investigate the correlation between Helicobacter pylori infection antibody typing and the degree and histological changes of gastric mucosa inflammatory lesions.Methods Clinical data of 162 patients who underwent gastroscopy,tissue biopsy and antibody testing for Helicobacter pylori infection at Suzhou High-tech Zone People's Hospital from September 2019 to September 2022 were collected.Immunoblotting was used to detect the expression and typing of serum Helicobacter pylori infection antibodies,and the degree of inflammatory lesions and histological changes of gastric mucosa were examined pathologically:the antibody typing of Helicobacter pylori infection in patients with different genders and ages were compared:the degree and histological changes of gastric mucosa inflammatory lesions in patients with different Helicobacter pylori infection antibody typing were compared;The correlation between Helicobacter pylori infection antibody typing,the degree of inflammatory lesions of gastric mucosa and histological changes were analyzed by Spearman correlation analysis.Results There was no significant difference in antibody typing of Helicobacter pylori infection among patients with different genders:type Ⅰ(χ^(2)=0.206,P=0.650),type Ⅱ(χ^(2)=0.523.P=0.469)and the overall positive rate(χ^(2)=0.956,P=0.328);There were significant differences in the positive rate of Helicobacter pylori type Ⅰ infection(χ^(2)=12.988.P=0.002)and the total positive rate(χ^(2)=7.694,P=0.021)among patients of different ages:There were statistically significant differences in the antibody typing of Helicobacter pylori infection(χ^(2)=15.589,P<0.001)and the proportion of type Ⅰ(P<0.001)among patients with different degrees of gastric mucosal inflammatory lesions.There was no significant difference in the positive rates of toxin-related gene A(CagA),vacuolating toxin gene A(VacA),and CagA+VacA positive rates among Helicobacter pylori type Ⅰ infection(Fisher's exact probability method:P=0.638,0.773,0.311).There were stat

关 键 词：胃黏膜炎性病变程度 胃黏膜组织学变化 胃癌 幽门螺杆菌 相关性 

分 类 号：R735.2[医药卫生—肿瘤]