基于分子生物学与免疫学技术的肿瘤综合实验课程的设计及思考  

Design and thinking of tumor comprehensive experimental course based on molecular biology and immunology technology

作　　者：杨明[1] 陈多多 房明丽[1] 王弘瑞 李冬[1] 苏盈盈[1] 杨巍[1] YANG Ming;CHEN Duoduo;FANG Mingli;WANG Hongrui;LI Dong;SU Yingying;YANG Wei(College of Basic Medical Sciences,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学基础医学院,长春130021

出　　处：《中国免疫学杂志》2024年第10期2180-2183,2188,共5页Chinese Journal of Immunology

基　　金：吉林大学本科教学改革研究项目(2021XYB184,2021XYB178);吉林大学研究生教育教学改革建设项目(2021JGY56);吉林省教育科学“十三五”规划一般课题(GH170007)。

摘　　要：为适应生命科学及医学全面发展的需要,实现本科生实验课程的连贯性和交叉性,需打破常规单一课程实验的教学内容,开展肿瘤综合实验课程的教学改革。分子生物学和免疫学是与生命科学、基础医学及临床医学的科学研究联系最为紧密的两门基础学科,也是学生获得技能训练与形成完善科学思维的重要助力来源。本研究将以肿瘤相关基因的分析及干预为切入点,尝试以分子生物学与免疫学技术为主体进行实验课程整合,初步探索建立新的肿瘤综合实验课程。课程注重学生逻辑思维的开发,通过数据库筛选、实验操作、实验汇报及论文撰写等多个环节模拟科研过程,以期望显著提高本科生对科研的兴趣和理论联系实际的能力,培养学生严谨的科学创新思维能力及全面分析问题和解决问题的能力,为将来研究生阶段相关的科学研究奠定坚实基础。同时,有助于培养具备多学科知识储备的师资力量,通过教学促进科研的协调发展。In order to meet the needs of the comprehensive development of life sciences and medicine,and fulfill the coher⁃ence and intersectionality of undergraduate experimental courses,it is necessary to break the teaching contents of conventional single experiment courses,and carry out the teaching reform of tumor comprehensive experimental course.Molecular biology and immunology are two basic subjects which are closely related to the scientific research of life science,basic medicine and clinical medicine.Meantime,they are important sources for students to acquire skill training and scientific thinking as well.In this study,we try to inte⁃grate the experimental courses about the analysis and intervention of tumor-related genes based on the molecular biology and immunology technologies,facilitating to establish a new tumor comprehensive experimental course system.The course focuses on the development of students'logical thinking,and simulates the scientific research process through database screening,experimental operation,experi⁃mental report and paper writing,so as to significantly improve undergraduates'interest in scientific research and their ability to com⁃bine theory with practice,and cultivate students'rigorous scientific and innovative thinking ability as well as their ability to compre⁃hensively analyze and solve problems.It lays a solid foundation for future postgraduate related scientific research.At the same time,it is helpful to train teachers with multi-disciplinary knowledge reserves,and promote the coordinated development of scientific research through teaching.

关 键 词：实验课 分子生物学 免疫学 整合 肿瘤 

分 类 号：R392.1[医药卫生—免疫学]