细胞自噬在胰腺炎症及纤维化中的研究进展  

Research progress of autophagy in pancreatic inflammation and fibrosis

作　　者：高合 许小凡[1] 段丽芳[1] 张红[1,2] GAO He;XU Xiaofan;DUAN Lifang;ZHANG Hong(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Shaanxi Province Immune Inflammation Related Diseases Prevention and Control of International Joint Research Center of Traditional Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学,咸阳712046 [2]陕西省免疫炎症相关疾病中医药防治国际联合研究中心,咸阳712046

出　　处：《中国免疫学杂志》2024年第10期2229-2235,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金(82174201,82104815);陕西中医药大学创新团队项目(2019-YL14);陕西省特支计划(303/141020047)。

摘　　要：慢性胰腺炎(CP)是一种进行性胰腺纤维炎症性疾病,其病理特征表现为胰腺腺泡细胞破坏、炎症细胞浸润、胰腺星状细胞(PSC)活化和胰腺纤维化。细胞自噬是参与细胞稳态维持的重要事件,近来研究显示细胞自噬与CP的发生发展密切相关,而胰腺微环境中的几种细胞自噬在CP进展中发挥着不同的作用,腺泡细胞自噬具有“双刃剑”的效应,PSC自噬与其活化呈正相关,而炎症细胞自噬的作用尚不清楚。本文聚焦于CP微环境中的几种关键细胞,探讨各种细胞自噬在CP进展中的作用和机制。Chronic pancreatitis(CP)is a progressive fibroinflammatory disease characterized by destruction of pancreatic aci⁃nar cells,infiltration of inflammatory cells,activation of pancreatic stellate cell(PSC),and pancreatic fibrosis.Autophagy partici⁃pates in the maintenance of cell homeostasis.Recent studies have shown that autophagy closely related to the occurrence and develop⁃ment of CP.However,several autophagy types in the pancreatic microenvironment play different roles in the progression of CP.The autophagy of acinar cells has a"double-edged sword"effect.PSC autophagy is positively correlated with its activation,while the role of autophagy of inflammatory cells is still unclear.This study focused on some key cells in the CP microenvironment and explored the role and mechanism of autophagy in the progression of CP.

关 键 词：慢性胰腺炎 胰腺纤维化 自噬 腺泡细胞 胰腺星状细胞 巨噬细胞 

分 类 号：R576[医药卫生—消化系统]