Novel insights on oral squamous cell carcinoma management using long non-coding RNAs  

作　　者：SUBHAYAN SUR DIMPLE DAVRAY SOUMYA BASU SUPRIYA KHEUR JAYANTA KUMAR PAL SHUCHI NAGAR AVINASH SANAP BHIMAPPA MRUDAGI SAMIR GUPTA 

机构地区：[1]Cancer and Translational Research Centre,Dr.D.Y.Patil Biotechnology and Bioinformatics Institute,Dr.D.Y.Patil Vidyapeeth,Tathawade,Pune,411033,India [2]Bioinformatics Centre,Dr.D.Y.Patil Biotechnology and Bioinformatics Institute,Dr.D.Y.Patil Vidyapeeth,Pune,411033,India [3]Department of Oral Pathology and Microbiology,Dr.D.Y.Patil Dental College&Hospital,Dr.D.Y.Patil Vidyapeeth,Pune,411018,India [4]Department of Surgical Oncology,Dr.D.Y.Patil Medical College,Hospital&Research Centre,Dr.D.Y.Patil Vidyapeeth,Pune,411018,India

出　　处：《Oncology Research》2024年第10期1589-1612,共24页肿瘤学研究（英文）

基　　金：the Ramalingaswami Re-Entry Fellowship,Department of Biotechnology,Govt.of India to S.Sur(BT/RLF/Re-Entry/47/2021).

摘　　要：Oral squamous cell carcinoma(OSCC)is one of the most prevalent forms of head and neck squamous cell carcinomas(HNSCC)with a poor overall survival rate(about 50%),particularly in cases of metastasis.RNA-based cancer biomarkers are a relatively advanced concept,and non-coding RNAs currently have shown promising roles in the detection and treatment of various malignancies.This review underlines the function of long non-coding RNAs(lncRNAs)in the OSCC and its subsequent clinical implications.LncRNAs,a class of non-coding RNAs,are larger than 200 nucleotides and resemble mRNA in numerous ways.However,unlike mRNA,lncRNA regulates multiple druggable and non-druggable signaling molecules through simultaneous interaction with DNA,RNA,proteins,or microRNAs depending on concentration and localization in cells.Upregulation of oncogenic lncRNAs and downregulation of tumor suppressor lncRNAs are evident in OSCC tissues and body fluids such as blood and saliva indicating their potential as valuable biomarkers.Targeted inhibition of candidate oncogenic lncRNAs or overexpression of tumor suppressor lncRNAs showed potential therapeutic roles in in-vivo animal models.The types of lncRNAs that are expressed differentially in OSCC tissue and bodily fluids have been systematically documented with specificity and sensitivity.This review thoroughly discusses the biological functions of such lncRNAs in OSCC cell survival,proliferation,invasion,migration,metastasis,angiogenesis,metabolism,epigenetic modification,tumor immune microenvironment,and drug resistance.Subsequently,we addressed the diagnostic and therapeutic importance of lncRNAs in OSCC pre-clinical and clinical systems,providing details on ongoing research and outlining potential future directions for advancements in this field.In essence,this review could be a valuable resource by offering comprehensive and current insights into lncRNAs in OSCC for researchers in fundamental and clinical domains.

关 键 词：Oral squamous cell carcinoma(OSCC) Head and neck cancer Non-coding RNA Long non-coding RNA(lncRNA) Cancer diagnosis 

分 类 号：R739.8[医药卫生—肿瘤]