鞘内药物输注系统联合疼痛管理对居家中晚期重度疼痛癌症患者的治疗效果  

Therapeutic effect of intrathecal drug delivery system combined with pain management on middle-and late-stage homebound severe cancer pain patients

作　　者：孙丽华 唐倩 顾光丽 范雪松 袁敏 SUN Lihua;TANG Qian;GU Guangli;FAN Xuesong;YUAN Min(Department of Pain,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou China;School of Nursing,Guizhou Medical University,Guiyang 550004,Guizhou,China)

机构地区：[1]贵州医科大学附属医院疼痛科,贵州贵阳550004 [2]贵州医科大学护理学院,贵州贵阳550004

出　　处：《贵州医科大学学报》2024年第9期1353-1359,共7页Journal of Guizhou Medical University

基　　金：贵州省卫生健康委科学技术基金项目(gzwkj2023-090)。

摘　　要：目的探讨鞘内药物输注系统(IDDS)联合疼痛管理对居家中晚期重度疼痛癌症患者的治疗效果。方法将70例接受IDDS治疗的中晚期重度疼痛癌症患者均分为对照组和试验组,所有患者接受IDDS治疗后留置鞘内药物输注导管出院,出院后对照组患者进行微信群随访、试验组患者接受基于微信群的疼痛管理干预并随访,时间为3个月;分别于干预前、干预3个月时,比较2组患者疼痛数字评分量表(NRS)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、癌痛自我效能量表(CPSS)、癌症患者生活质量测定量表(QLQ-C30)评分。结果两组患者一般资料及干预前的NRS、SAS、SDS、CPSS、QLQ-C30评分比较,差异无统计学意义(P>0.05);干预3个月时,试验组患者的NRS、SAS及SDS评分低于对照组,QLQ-C30的症状领域得分低于对照组,CPSS各维度得分QLQ-C30的功能领域、总体健康状况领域得分高于对照组,差异有统计学意义(P<0.001)。结论鞘内药物输注系统联合疼痛管理可减轻居家癌痛患者的疼痛程度,改善癌痛患者焦虑、抑郁情绪,提高患者自我效能,优化居家生活质量。Objective To investigate therapeutic effect of intrathecal drug delivery system(IDDS)combined with pain management on middle-and late-stage homebound severe cancer pain patients.Methods A total of 70 cancer severe pain patients treated with IDDS were randomly divided into control and observation groups.All patients kept an indwelling intrathecal drug delivery catheter when they were discharged.After discharge,the patients in control group were followed up via WeChat,while the patients in observation group was given with pain management intervention based on WeChat.Follow-up lasted for 3 months.Two groups of patients were compared for numeric rating scale(NRS)for pain,self-rating anxiety scale(SAS),self-rating depression scale(SDS),cancer pain self efficacy scale(CPSS),and cancer patient quality of life scale(QLQ-C30)between before and after 3 months of intervention.Results There were no statistically significant differences in general information,NRS,SAS,SDS,CPSS,and QLQ-C30 scores before intervention between two groups of patients(P>0.05).At 3 months of intervention,NRS,SAS,and SDS scores and the scores of CPSS dimensions and QLQ-C30 symptom domains were lower in observation group than those in control group,while the scores of QLQ-C30 functional domains and overall health status were higher than those in control group(P<0.001).Conclusion Intrathecal drug delivery system combined with pain management may alleviate pain level of homebound cancer pain patients,reduce the anxiety and depression of cancer pain patients,improve self-efficacy of the patients,and optimize quality of life at home.

关 键 词：鞘内药物输注系统 癌性疼痛 居家管理 疼痛管理 生活质量 

分 类 号：R730.5[医药卫生—肿瘤]