盐酸金刚烷胺对大鼠膀胱功能的双相作用  

Biphasic Effect of Amantadine Hydrochloride on Bladder Function in Rats

作　　者：刘洋[1] 刘志[2] 金嘉慧[2] 孙可 任俊 权美龄 王立英[1] 刘文革[2] LIU Yang;LIU Zhi;JIN Jiahui;SUN Ke;REN Jun;QUAN Meiling;WANG Liying;LIU Wenge(Basic Medicine College of Beihua University,Jilin 132013,China;Jilin Central Hospital,Jilin 132011,China)

机构地区：[1]北华大学基础医学院,吉林吉林132013 [2]吉林市中心医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2024年第6期801-804,共4页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(JJKH20210057KJ);吉林省自然科学基金项目(YDZJ202201ZYTS172);北华大学大学生创新创业训练项目(202310201152,202410201042,202410201091)。

摘　　要：目的探讨不同剂量盐酸金刚烷胺对大鼠膀胱功能的影响。方法在清醒和自由活动状态下,给予成年雄性Sprague-Dawley大鼠不同剂量盐酸金刚烷胺(0.3、3、30、100μmol/kg)或安慰剂(生理盐水),连续记录(60 m in)、分析大鼠膀胱功能尿动力学参数。结果安慰剂组给药后尿动力学参数没有明显变化(P>0.05);3μmol/kg盐酸金刚烷胺组大鼠给药后膀胱容量明显增加,排尿间隔时间明显延长(P<0.05);100μmol/kg盐酸金刚烷胺组大鼠给药后,膀胱容量明显减少,排尿间隔时间明显缩短(P<0.05);各剂量盐酸金刚烷胺大鼠膀胱收缩压及残余尿量均未产生明显变化(P>0.05)。结论盐酸金刚烷胺对大鼠膀胱功能具有剂量依赖性的双相作用。Objective To explore the effects of different doses of amantadine hydrochloride on bladder function in rats.Method Adult male Sprague-Dawley rats were administered different doses of amantadine hydrochloride(0.3,3,30,100μmol/kg)or saline in a conscious and free movement state,and the bladder function urodyn-amic parameters of the rats were continuously recorded and analyzed for 60 minutes.Results There was no significant change in urodynamic parameters in the saline group after administration(P>0.05);The bladder capacity of rats was increased after administration in medium-dose(3μmol/kg)amantadine hydrochloride group,the voiding interval was prolonged(P<0.05).The bladder capacity of rats was decreased after administration in high-dose(100μmol/kg)amantadine hydrochloride group,the voiding interval was shorten(P<0.05).All doses of amantadine hydrochloride did not show significant change in maximum bladder contraction pressure and post voiding residual volume(P>0.05).Conclusion Amantadine hydrochloride has a dose-dependent biphasic effect on bladder function in rats.

关 键 词：帕金森病 膀胱功能 尿动力学 金刚烷胺 

分 类 号：R741.04[医药卫生—神经病学与精神病学] R741.05[医药卫生—临床医学]