肠道菌群在青少年抑郁障碍发病机制中的研究  

The Study of Intestinal Flora in the Pathogensis of Adolescent Depressive Disorders

作　　者：邓先武 郭晓雯 张琦 寻广磊[2] DENG Xianwu;GUO Xiaowen;ZHANG Qi;XUN Guanglei(School of Mental Health,Jining Medical University,Jining 272075,Shandong,China;Department of Psychiatry,Shandong Mental Health Center,Jinan 250014,Shandong,China)

机构地区：[1]济宁医学院精神卫生学院,山东济宁272075 [2]山东省精神卫生中心精神科,山东济南250014

出　　处：《系统医学》2024年第15期191-194,共4页Systems Medicine

摘　　要：抑郁障碍现已成为严重威胁青少年心理健康的主要问题。目前,对青少年抑郁障碍患者而言,首选抗抑郁药物,疗效有限,且不良反应较多。鉴于青少年抑郁障碍可能是抑郁症的一个特殊亚型,探索新的治疗方法变得尤为重要。近期的研究表明,调节肠道菌群能有效改善抑郁症状,主要通过微生物-肠-脑轴(microbiota-gut-brain axis, MGB)的双向沟通机制体现。本文综述了肠道菌群的组成和功能,并详细讨论了肠道菌群在青少年抑郁障碍的作用机制。文章还概括了肠道菌群在青少年抑郁障碍治疗中的临床应用前景,旨在为青少年抑郁障碍进一步研究提供参考。Depression disorders have become a serious threat to the mental health of adolescents.Currently,for ado-lescents with depressive disorders,the efficacy of first-line antidepressant medications is limited with more adverse re-actions.Given that adolescent depression disorders may represent a specific subtype of depression,exploring new treatment approaches becomes particularly important.Recent studies have shown that modulating the gut microbiota can effectively improve depressive symptoms,mainly through the bidirectional communication mechanism of the microbiota-gut-brain axis(MGB).This article reviews the composition and function of the gut microbiota,and dis-cusses in detail the mechanisms of action of the gut microbiota in adolescent depression disorders.The article also summarizes the clinical prospects of the gut microbiota in the treatment of adolescent depression disorders,aiming to provide reference for further research on adolescent depression disorders.

关 键 词：肠道菌群 青少年 抑郁障碍 治疗 

分 类 号：R4[医药卫生—临床医学]