Tmem16a、E-cadherin、SIRT1在眼睑基底细胞癌中的表达及其临床意义  

Expression Levels and Clinical Significance of Tmem16a,E-cadherin and SIRT1 in Eyelid Basal Cell Carcinoma

作　　者：李琰 尚利晓[1] 谢琦莲 LI Yan;SHANG Lixiao;XIE Qilian(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000

出　　处：《实用癌症杂志》2024年第10期1597-1600,共4页The Practical Journal of Cancer

摘　　要：目的分析跨膜蛋白16a(Tmem16a)、钙黏蛋白E(E-cadherin)、沉默信息调节因子1(SIRT1)在眼睑基底细胞癌中表达水平及其临床意义。方法将70例经病理检查证实为眼睑基底细胞癌患者手术切除的癌组织纳入研究组,其癌周正常组织纳入对照组。术后随访36个月观察复发情况。比较癌组织及癌周正常组织中Tmem16a、E-cadherin、SIRT1表达水平,不同性别、年龄、不同病理特征患者癌组织中Tmem16a、E-cadherin、SIRT1表达水平,癌组织中Tmem16a、E-cadherin、SIRT1表达水平与复发的关系。结果癌组织中Tmem16a、E-cadherin、SIRT1表达水平高于癌周正常组织(P<0.05)。相比年龄≤60岁的眼睑基底细胞癌患者,年龄≥60岁的患者癌组织中Tmem16a、E-cadherin、SIRT1表达水平更高(P<0.05)。肿瘤体积≥3 cm^(3)、脉管侵犯、分化的眼睑基底细胞癌患者癌组织Tmem16a、E-cadherin、SIRT1表达水平更高(P<0.05)。癌组织中Tmem16a阳性表达眼睑基底细胞癌患者复发率为44.44%(16/36),高于阴性表达患者[20.59%(7/34)],P<0.05;癌组织中E-cadherin阳性表达眼睑基底细胞癌患者复发率为56.67%(17/30),高于阴性表达患者[15.00%(6/40)],P<0.05;癌组织中SIRT1阳性表达眼睑基底细胞癌患者复发率为40.00%(22/55),高于阴性表达患者[6.67%(1/15)],P<0.05。结论眼睑基底细胞癌患者癌组织Tmem16a、E-cadherin、SIRT1阳性表达水平更高,其表达与其病理特征、年龄、复发情况密切相关,可为评估病情进展和预后提供参考。Objective To analyze the expression levels of transmembrane protein 16a(Tmem16a),cadherin E(E-cadherin)and silence-information regulator 1(SIRT1)in eyelid basal cell carcinoma and their clinical significance.Methods 70 patients with basal cell carcinoma of the eyelid confirmed by pathological examination were included in the study group,and their pericancerous tissues were included in the control group.The recurrence was observed after 36 months follow-up.The expression levels of Tmem16a,E-cadherin and SIRT1 in cancer tissues and pericancerous normal tissues were compared,and the expression levels of Tmem16a,E-cadherin and SIRT1 in cancer tissues of patients with different gender,age and pathological characteristics were compared.Relationship between the expression levels of Tmem16a,E-cadherin,SIRT1 and recurrence in cancer tissues.Results The expression levels of Tmem16a,E-cadherin and SIRT1 in cancer tissues were higher than those in normal tissues(P<0.05).Compared with patients aged≤60 years,the expression levels of Tmem16a,E-cadherin and SIRT1 in cancer tissues of patients aged≥60 years were higher(P<0.05).The expression levels of Tmem16a,E-cadherin and SIRT1 were higher in eyelid basal cell carcinoma patients with tumor volume≥3 cm^(3),vascular invasion and differentiation(P<0.05).The recurrence rate of patients with basal cell carcinoma with positive expression of Tmem16a was 44.44%(16/36),which was higher than that of patients with negative expression[20.59%(7/34)],P<0.05.The recurrence rate of patients with basal cell carcinoma with positive expression of E-cadherin was 56.67%(17/30),which was higher than that of patients with negative expression[15.00%(6/40)],P<0.05.The recurrence rate of patients with eyelid basal cell carcinoma with SIRT1 positive expression was 40.00%(22/55),which was higher than that of patients with negative expression[6.67%(1/15)],P<0.05.Conclusion The positive expression levels of Tmem16a,E-cadherin and SIRT1 in patients with eyelid basal cell carcinoma are higher,and their

关 键 词：眼睑基底细胞癌 跨膜蛋白16a 钙黏蛋白E 沉默信息调节因子1 表达水平 临床意义 

分 类 号：R739.71[医药卫生—肿瘤]