MMP9、AEG-1及EphA7蛋白在中耳鳞癌组织中的表达及其临床意义  

Expression of MMP9,AEG-1 and EphA7 Proteins in Middle Ear Squamous Cell Carcinoma and Their Clinical Significance

作　　者：朱丽丽[1] 陈晓君[1] 朱晓丹 刘梦君 ZHU Lili;CHEN Xiaojun;ZHU Xiaodan(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000 [2]新乡医学院第三附属医院,453700

出　　处：《实用癌症杂志》2024年第10期1601-1603,1607,共4页The Practical Journal of Cancer

摘　　要：目的探讨基质金属蛋白酶-9(MMP-9)、星形细胞提升基因-1(AEG-1)、络氨酸蛋白激酶受体A7(EphA7)蛋白在中耳鳞癌组织中的表达及其意义。方法选取65例中耳鳞癌患者作为研究对象,均行手术治疗,术中采集癌组织及癌旁正常组织送检,检测MMP-9、AEG-1、EphA7蛋白表达情况,比较癌组织与癌旁正常组织内上述表达差异;并分析MMP-9、AEG-1、EphA7蛋白表达与年龄、性别、肿瘤分期、淋巴结转移、分化程度等病理特征的关系。结果癌组织内MMP-9、AEG-1、EphA7蛋白阳性表达率高于癌旁正常组织,差异有统计学意义(P<0.05);MMP-9、AEG-1、EphA7蛋白阳性表达患者Ⅲ~Ⅳ期、有淋巴结转移占比高于阴性表达患者,差异有统计学意义(P<0.05)。结论MMP-9、AEG-1、EphA7蛋白在中耳鳞癌组织内呈高表达状况,且其表达与肿瘤分期、淋巴结转移关系密切,或可作为临床治疗的新靶点。Objective To investigate the expression and significance of matrix metalloproteinase-9(MMP-9),astrocyte promoter gene-1(AEG-1)and tyrosine protein kinase receptor A7(EphA7)in middle ear squamous cell carcinoma.Methods 65 patients with middle ear squamous cell carcinoma were selected as the study subjects,all of whom underwent surgical treatment.The expression of MMP-9,AEG-1 and EphA7 protein in cancer tissues and adjacent normal tissues were detected during the operation,and the above expression differences were compared between cancer tissues and adjacent normal tissues.The relationship between the expression of MMP-9,AEG-1 and EphA7 protein and the pathological characteristics of age,sex,tumor stage,lymph node metastasis and differentiation was analyzed.Results The positive expression rates of MMP-9,AEG-1 and EphA7 proteins in cancer tissues were higher than those in adjacent normal tissues,with statistical significance(P<0.05).Patients with positive expression of MMP-9,AEG-1 and EphA7 protein had higher proportion of stageⅢ~Ⅳand lymph node metastasis than those with negative expression,and the difference was statistically significant(P<0.05).Conclusion MMP-9,AEG-1 and EphA7 proteins are highly expressed in middle ear squamous cell carcinoma,and their expression is closely related to tumor stage and lymph node metastasis,which may be a new target for clinical treatment.

关 键 词：中耳鳞癌 基质金属蛋白酶-9 星形细胞提升基因-1 络氨酸蛋白激酶受体A7 

分 类 号：R739.61[医药卫生—肿瘤]