三阴性乳腺癌组织中EGR1、AR、H3K4me3表达与其临床病理特征及预后的相关性  

Correlation Between the Expression of EGR1,AR,H3K4me3 and Clinicopathological Characteristics and Prognosis in Triple Negative Breast Cancer

作　　者：王丽[1] 杜闯 张亚青 李聪[1] 王静[1] WANG Li;DU Chuang;ZHANG Yaqing(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第10期1604-1607,共4页The Practical Journal of Cancer

摘　　要：目的探讨三阴性乳腺癌组织中早期生长反应基因1(EGR1)、雄激素受体(AR)、组蛋白H3第4位赖氨酸三甲基化(H3K4me3)表达与其临床病理特征及预后的相关性。方法回顾性分析89例三阴性乳腺癌患者的临床资料,所有患者均行手术治疗,采用免疫组化染色法测定EGR1、AR、H3K4me3表达,比较肿瘤组织及癌旁正常组织内EGR1、AR、H3K4me3表达差异,分析EGR1、AR、H3K4me3表达与其临床病理的关系,分析EGR1、AR、H3K4me3表达与其预后的关系。结果肿瘤组织内EGR1阳性表达率、AR阳性表达率低于对照组,H3K4me3阳性表达率高于对照组,差异有统计学意义(P<0.05);EGR1阳性表达、AR阳性表达患者临床分期Ⅰ~Ⅱ期、无淋巴结转移、中高分化占比高于EGR1阴性表达、AR阴性表达患者,H3K4me3阳性表达患者临床分期Ⅲ期、淋巴结转移、低分化占比高于H3K4me3阴性表达患者,差异有统计学意义(P<0.05);随访1年,89例患者共36例出现复发转移,发生率为40.45%(36/89);复发转移组EGR1阳性表达、AR阳性表达率低于未复发转移组,H3K4me3阳性表达率高于未复发转移组,差异有统计学意义(P<0.05)。结论EGR1、AR在三阴性乳腺癌中多呈阴性表达,H3K4me3则以阳性表达为主,三者表达均与临床分期、淋巴结转移及分化程度存在密切关系,或可作为临床治疗的新靶点。Objective To investigate the correlation between the expression of early growth response gene 1(EGR1),androgen receptor(AR),and histone H3 fourth lysine trimethylation(H3K4me3)in triple negative breast cancer tissues and their clinicopathological features and prognosis.Methods The clinical data of 89 patients with triple-negative breast cancer were retrospectively analyzed.All patients underwent surgical treatment.The expression of EGR1,AR and H3K4me3 in tumor tissues and adjacent normal tissues were measured by immunohistochemical staining.To analyze the relationship between EGR1,AR,H3K4me3 expression and its clinicopathology,and to analyze the relationship between EGR1,AR,H3K4me3 expression and prognosis.Results The positive expression rate of EGR1 and AR in tumor tissues was lower than that in the control group,and the positive expression rate of H3K4me3 was higher than that in control group,with statistical significance(P<0.05).In patients with positive expression of EGR1 and positive expression of AR,the proportion of clinical stageⅠ~Ⅱ,no lymph node metastasis and high differentiation was higher than that in patients with negative expression of EGR1 and negative expression of AR,and the proportion of clinical stageⅢ,lymph node metastasis and low differentiation in patients with positive expression of H3K4me3 was higher than that in patients with negative expression of H3K4me3.The difference was statistically significant(P<0.05).After 1 year of follow-up,36 of 89 patients had recurrence and metastasis,the incidence was 40.45%(36/89).The positive expression rate of EGR1 and AR in the relapsing and metastasis group was lower than that in the non-relapsing and metastasis group,and the positive expression rate of H3K4me3 was higher than that in the non-relapsing and metastasis group,with statistical significance(P<0.05).Conclusion EGR1 and AR are mostly negative expression in triple-negative breast cancer,while H3K4me3 is mainly positive expression.The expressions of all three are closely related to clinica

关 键 词：三阴性乳腺癌 早期生长反应基因1 雄激素受体 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]