鼻咽癌组织中VEGF及受体、CXCL10、PDK1表达与复发转移的相关性  

Correlation Analysis of VEGF and Its Receptors,CXCL10,PDK1 Expression with Recurrence and Metastasis in Nasopharyngeal Carcinoma Tissue

作　　者：李玉宁 黄小芳 王淑云[1] 陈加艳 LI Yuning;HUANG Xiaofang;WANG Shuyun(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第10期1614-1617,共4页The Practical Journal of Cancer

摘　　要：目的探讨鼻咽癌组织内血管内皮生长因子(VEGF)及受体、趋化因子配体10(CXCL10)、丙酮酸脱氢酶激酶-1(PDK1)表达与复发转移间的关系。方法回顾性分析89例鼻咽癌患者临床资料,放疗前采集所有患者肿瘤组织及癌旁正常组织,开展免疫组化SP法检测VEGF、VEGF受体-2(VEGFR-2)、CXCL10、PDK1表达,并比较其在肿瘤组织及癌旁正常组织中表达的差异性;比较不同年龄、性别、肿瘤分期、淋巴结转移患者间VEGF及受体、CXCL10、PDK1表达的差异。随访2年,统计复发转移情况及其与VEGF及受体、CXCL10、PDK1表达间的关系。结果肿瘤组织内VEGF及受体、CXCL10、PDK1阳性表达高于癌旁正常组织,差异有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期、有淋巴结转移患者VEGF及受体、CXCL10、PDK1阳性表达率高于临床分期Ⅰ~Ⅱ期、无淋巴结转移患者,差异有统计学意义(P<0.05)。随访2年,89例中27例复发转移,复发转移率为30.34%(27/89);复发转移患者VEGF及受体、CXCL10、PDK1阳性表达率高于未复发转移患者,差异有统计学意义(P<0.05)。结论VEGF及受体、CXCL10、PDK1在鼻咽癌组织中存在较高表达,其高表达与肿瘤复发转移关系密切,临床需高度重视,以完善早期治疗方案。Objective To investigate the relationship between the expression of vascular endothelial growth factor(VEGF),its receptor,chemokine ligand 10(CXCL10),pyruvate dehydrogenase kinase-1(PDK1)and recurrence and metastasis in nasopharyngeal carcinoma.Methods The clinical data of 89 patients with nasopharyngeal carcinoma were retrospectively analyzed.The expression of VEGF,VEGF receptor-2(VEGFR-2),CXCL10 and PDK1 were detected by immunohistochemical SP method before radiotherapy,and the differences of expression between tumor tissues and adjacent normal tissues were compared.The expression of VEGF and its receptor,CXCL10 and PDK1 among patients with different age,sex,tumor stage and lymph node metastasis were compared.After 2 years of follow-up,the recurrence and metastasis and their relationship with the expression of VEGF and its receptor,CXCL10 and PDK1 were analyzed.Results The positive expressions of VEGF and receptor,CXCL10 and PDK1 in tumor tissues were higher than those in adjacent normal tissues,and the differences were statistically significant(P<0.05).The positive expression rates of VEGF,receptor,CXCL10 and PDK1 in patients with clinical stageⅢtoⅣand lymph node metastasis were higher than those in patients with clinical stageⅠtoⅡand no lymph node metastasis,and the difference was statistically significant(P<0.05).After 2 years of follow-up,there were 27 recurrence and metastasis in 89 cases,and the recurrence and metastasis rate was 30.34%(27/89).The positive expression rates of VEGF and receptor,CXCL10 and PDK1 in patients with recurrence and metastasis were higher than those without recurrence and metastasis,and the difference was statistically significant(P<0.05).Conclusion VEGF and its receptor,CXCL10 and PDK1 are highly expressed in nasopharyngeal carcinoma tissues,and their high expression is closely related to tumor recurrence and metastasis.Clinical attention should be paid to improve early treatment.

关 键 词：鼻咽癌 血管内皮生长因子 趋化因子配体10 丙酮酸脱氢酶激酶-1 复发转移 

分 类 号：R739.63[医药卫生—肿瘤]