BAG3蛋白在宫颈癌和癌前病变组织中的表达及临床意义  

The Expression and Clinical Significance of BAG3 Protein in Cervical Cancer and Precancerous Lesions Tissues

作　　者：黄珂 姜清芳 HUANG Ke;JIANG Qingfang(Kaifeng Obstetrics and Gynecology Hospital,Kaifeng,475000)

机构地区：[1]河南省开封市妇产医院,475000 [2]河南省开封市肿瘤医院,475000

出　　处：《实用癌症杂志》2024年第10期1626-1629,共4页The Practical Journal of Cancer

摘　　要：目的探讨Bcl-2相关抗凋亡基因3(BCL2-associated athanogene-3,BAG3)在宫颈癌和癌前病变组织中的表达水平及临床意义。方法选取201例宫颈组织标本为研究对象,其中宫颈癌组织标本70例(宫颈癌组)、低级别鳞状上皮内病变组织标本46例(LSIL组)、高级别鳞状上皮内病变组织标本50例(HSIL组)和宫颈正常组织标本35例(正常组)。随后采用免疫组织化学染色法检测所有标本组织中BAG3蛋白表达水平,并分析BAG3蛋白表达与宫颈癌临床病理特征以及预后的关系。结果BAG3蛋白在宫颈癌组中的高表达率明显高于HSIL组、LSIL组、正常组(宫颈癌组>HSIL组>LSIL组>正常组,P<0.05)。BAG3蛋白表达与宫颈癌分化程度、淋巴结转移存在显著关系,低分化、淋巴结转移的宫颈癌患者BAG3蛋白高表达率更高(P<0.05)。70例宫颈癌患者3年生存率为60.00%,其中BAG3高表达、低表达患者3年生存率分别为53.57%(30/56)、85.71%(12/14),二者3年生存率差异存在统计学意义(P<0.05)。单因素分析结果显示:宫颈癌预后与分化程度、淋巴结转移、BAG3表达有关(P<0.05),多因素Cox分析结果显示,低分化、淋巴结转移、BAG3高表达均为影响宫颈癌患者预后的独立危险因素(P<0.05)。结论BAG3蛋白在宫颈癌和癌前病变组织中表达高于宫颈正常组织,且表达水平与宫颈癌分化程度、淋巴结转移有关。BAG3蛋白高表达是宫颈癌预后危险因素,其有望作为临床诊治宫颈癌的有效生物标志物。Objective To investigate the expression levels and clinical significance of Bcl-2 associated apoptosis gene 3(BCL2-associated apoptosis-3,BAG3)in cervical cancer and precancerous lesions.Methods 201 cervical tissue samples were selected as the research subjects,including 70 cervical cancer tissue samples(cervical cancer group),46 low-grade squamous intraepithelial lesions tissue samples(LSIL group),50 high-grade squamous intraepithelial lesions tissue samples(HSIL group),and 35 normal cervical tissue samples(normal group).Subsequently,immunohistochemical staining was used to detect the expression level of BAG3 protein in all specimen tissues,and the relationship between BAG3 protein expression and clinical pathological characteristics as well as prognosis of cervical cancer was analyzed.Results The high expression rate of BAG3 protein in the cervical cancer group was significantly higher than that in the HSIL group,LSIL group,and normal group(cervical cancer group>HSIL group>LSIL group>normal group,P<0.05).There was a significant relationship between the expression of BAG3 protein and the degree of differentiation and lymph node metastasis of cervical cancer.Cervical cancer patients with low differentiation and lymph node metastasis had a higher expression rate of BAG3 protein(P<0.05).The 3-year survival rate of 70 cervical cancer patients was 60.00%.Among them,the 3-year survival rates of patients with high and low expression of BAG3 were 53.57%(30/56)and 85.71%(12/14),respectively.There was a statistical significant difference in the 3-year survival rates between the two(P<0.05).The results of univariate analysis showed that the prognosis of cervical cancer was related to the degree of differentiation,lymph node metastasis,and BAG3 expression(P<0.05).The results of multivariate Cox analysis showed that low differentiation,lymph node metastasis,and high BAG3 expression were independent risk factors affecting the prognosis of cervical cancer patients(P<0.05).Conclusion The expression of BAG3 protein is higher in

关 键 词：Bcl相关抗凋亡蛋白3 宫颈癌 癌前病变 临床意义 

分 类 号：R737.33[医药卫生—肿瘤]