DSA灌注成像技术在晚期肝癌患者DEB-TACE术后短期效果评估中的应用价值  

Application Value of Digital Subtraction Angiography Perfusion Imaging Technology in Short-term Efficacy Evaluation of DEB-TACE in Patients with Advanced Liver Cancer

作　　者：于庆[1] 杨春英[1] 靳海英[1] YU Qing;YANG Chunying;JIN Haiying(Huaihe Hospital,Henan University,Kaifeng,475000)

机构地区：[1]河南大学淮河医院,475000

出　　处：《实用癌症杂志》2024年第10期1639-1642,共4页The Practical Journal of Cancer

摘　　要：目的探究数字减影血管造影(DSA)灌注成像技术在晚期肝癌患者药物洗脱微球-经动脉化疗栓塞术(DEB-TACE)术后短期效果评估中的应用价值。方法选取164例行DEB-TACE术的晚期肝癌患者作为研究对象,根据患者术后短期疗效分成OR组(完全缓解+部分缓解),非OR组(疾病稳定+疾病进展)。患者在术后均行DSA灌注成像技术检测;受试者工作特征(ROC)曲线分析DSA灌注成像技术对DEB-TACE术后短期效果的诊断价值。结果164例患者经DEB-TACE术治疗,完全缓解49例,部分缓解55例,疾病稳定53例,疾病进展7例。非OR组患者到达时间显著低于OR组(P<0.05),达峰时间、充盈率、曲线宽度和平均通过时间显著高于OR组(P<0.05)。根据ROC曲线得知,到达时间诊断DEB-TACE术后短期效果的曲线下面积(AUC)为0.891,灵敏度为74.12%,特异度为88.47%;达峰时间诊断DEB-TACE术后短期效果的AUC为0.900,灵敏度为76.37%,特异度为85.75%;充盈率诊断DEB-TACE术后短期效果的AUC为0.875,灵敏度为78.67%,特异度为83.78%;曲线宽度诊断DEB-TACE术后短期效果的AUC为0.859,灵敏度为79.67%,特异度为81.75%;平均通过时间诊断DEB-TACE术后短期效果的AUC为0.885,灵敏度为80.24%,特异度为78.54%。五者联合诊断DEB-TACE术后短期效果的AUC为0.993,灵敏度为93.24%,特异度为75.34%。五者联合诊断优于各自单独诊断(Z_(联合vs到达时间)=4.078、Z_(联合vs达峰时间)=3.443,Z_(联合vs充盈率)=4.068,Z_(联合vs曲线宽度)=4.466,Z_(联合vs平均通过时间)=3.723,P均<0.05)。结论DSA灌注成像技术在晚期肝癌患者DEB-TACE术后短期效果评估中有较好的应用价值,可以提供较为客观的依据。Objective To explore the application value of digital subtraction angiography(DSA)perfusion imaging technology in short-term efficacy evaluation of drug eluting beads-transcatheter arterial chemoembolization(DEB-TACE)in patients with advanced liver cancer.Methods 164 patients with advanced hepatocellular carcinoma who underwent DEB-TACE were selected as study subjects,and the patients were divided into OR group(complete remission+partial remission)and non-OR group(stable disease+disease progression)according to their short-term postoperative outcomes.All patients underwent DSA perfusion imaging technology testing after surgery;receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of DSA perfusion imaging technology for short-term outcomes after DEB-TACE surgery.Results 164 patients were treated after DEB-TACE,49 in complete remission,55 in partial remission,53 in stable disease,and 7 in disease progression.The arrival time of patients in the non OR group was obviously lower than that in the OR group(P<0.05),while the peak time,filling rate,curve width,and average passage time were obviously higher than those in the OR group(P<0.05).According to the receiver operating characteristic,the area under the curve(AUC)of arrival time in diagnosing short-term effect after DEB-TACE was 0.891,the sensitivity was 74.12%,and the specificity was 88.47%.The AUC of peak time in diagnosing short-term effects after DEB-TACE was 0.900,with a sensitivity of 76.37%and a specificity of 85.75%.The AUC of filling rate in diagnosing short-term effects after DEB-TACE was 0.875,sensitivity was 78.67%,and specificity was 83.78%.The AUC of curve width in diagnosing short-term effects after DEB-TACE was 0.859,the sensitivity was 79.67%,and the specificity was 81.75%.The AUC of average passage time in diagnosing short-term effects after DEB-TACE was 0.885,the sensitivity was 80.24%,and the specificity was 78.54%.The AUC of the five combination in diagnosing short-term effects after DEB-TACE was 0.993,the sensi

关 键 词：数字减影血管造影灌注成像技术 晚期肝癌 药物洗脱微球-经动脉化疗栓塞术 短期效果 评估 

分 类 号：R735.7[医药卫生—肿瘤]