原发性肝癌患者TACE术后综合征的危险因素分析  

Risk Factors Analysis of Post TACE Syndrome in Patients with Primary Liver Cancer

作　　者：胡艳艳[1] HU Yanyan(Zhengzhou Third People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省郑州市第三人民医院,450000

出　　处：《实用癌症杂志》2024年第10期1643-1645,1654,共4页The Practical Journal of Cancer

摘　　要：目的探讨原发性肝癌经皮肝动脉化疗栓塞(TACE)术后综合征临床表现及相关影响因素。方法回顾性分析89例原发性肝癌患者的临床资料,均行TACE术治疗,依据是否发生术后综合征分为两组,通过查阅病例资料、电话随访等多种方式收集两组基础资料行Logistic回归分析,获得影响原发性肝癌TACE术后综合征的独立危险因素。结果89例患者共44例发生术后综合征,发生率为49.44%(44/89);其中恶心呕吐15例(34.09%)、发热8例(18.18%)、肝区疼痛7例(15.91%)、腹胀9例(20.45%)、肝功能损害5例(11.36%);两组年龄、合并肝硬化、碘油剂量、肿瘤大小、Child分级相比,差异有统计学意义(P<0.05);多因素显示,年龄≥60岁、合并肝硬化、碘油剂量≥10 ml、巨块型肿瘤及Child分级B级为影响原发性肝癌TACE术后综合征的高危因素(P<0.05且OR>1)。结论原发性肝癌TACE术后综合征发生风险较高,与年龄≥60岁、合并肝硬化、碘油剂量≥10 ml、巨块型肿瘤及Child分级B级关系密切,还需尽早开展针对性干预,减少术后综合征发生。Objective To investigate the clinical manifestations and related factors of syndrome after percutaneous arterial chemoembolization(TACE)for primary liver cancer.Methods The clinical data of 89 patients with primary liver cancer were retrospectively analyzed,all of whom were treated with TACE.They were divided into 2 groups according to whether postoperative syndrome occurred.The basic data of the 2 groups were collected by consulting case data and telephone follow-up for Logistic regression analysis,and the independent risk factors affecting postoperative syndrome of primary liver cancer were obtained.Results A total of 44 of 89 patients developed postoperative syndrome(49.44%(44/89)).There were 15 cases of nausea and vomiting(34.09%),8 cases of fever(18.18%),7 cases of hepatic pain(15.91%),9 cases of abdominal distension(20.45%),and 5 cases of liver function impairment(11.36%).There were significant differences in age,cirrhosis,iodide dose,tumor size and Child grade between the 2 groups(P<0.05).Multiple factors showed that age≥60 years old,cirrhosis,iodide dose≥10 ml,massive tumor and Child grade B were high risk factors for TACE postoperative syndrome of primary liver cancer(P<0.05 and OR>1).Conclusion The risk of syndrome after TACE surgery for primary liver cancer is high,which is closely related to age≥60 years,cirrhosis,iodide dose≥10 ml,massive tumor and Child grade B.Targeted intervention should be carried out as soon as possible to reduce the incidence of postoperative syndrome.

关 键 词：原发性肝癌 经皮肝动脉化疗栓塞 术后综合征 临床表现 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]