早期声门型喉癌低温等离子射频消融术的临床疗效及对患者血清VEGF、MMP-9、NO水平的影响  

Clinical Efficacy of Low Temperature Plasma Radiofrequency Ablation for Early Glottic Laryngeal Cancer and Its Effect on Serum Levels of VEGF,MMP-9 and NO

作　　者：王芳 张瑞芹 胡云磊 WANG Fang;ZHANG Ruiqin;HU Yunlei(Xinyang Central Hospital,Xinyang,464000)

机构地区：[1]河南省信阳市中心医院,464000

出　　处：《实用癌症杂志》2024年第10期1650-1654,共5页The Practical Journal of Cancer

摘　　要：目的探讨低温等离子射频消融术(RFA)在早期声门型喉癌(GC)治疗中的价值。方法选取98例早期GC患者,随机分为对照组(n=47)与观察组(n=51)。对照组予以常规喉裂开术治疗,观察组接受低温等离子RFA治疗。统计2组围术期指标、疗效、并发症发生率、复发率,比较术前、术后3个月2组嗓音声学(振幅微扰、基频微扰、谐噪比)及血清基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)、一氧化氮(NO)水平。结果随访截止至2023年9月,期间对照组失访1例,未依从1例,最终纳入45例;观察组自行退出1例,失访1例,最终纳入49例。2组总有效率、复发率比较,差异无统计学意义(P>0.05)。对照组手术时间、创面上皮化时间、住院时间均长于观察组,术中出血量多于观察组(P<0.05)。术后3个月2组振幅微扰、基频微扰低于术前,谐噪比高于术前;且观察组谐噪比高于对照组,基频及振幅微扰低于对照组(P<0.05)。术后3个月2组血清MMP-9、VEGF、NO值低于术前,且观察组上述血清因子水平低于对照组(P<0.05)。对照组并发症发生率为20.00%,高于观察组的4.08%(P<0.05)。结论低温等离子RFA治疗早期GC,可优化围术期指标,改善血清MMP-9、VEGF、NO水平,促进嗓音声学恢复,降低并发症发生风险。Objective To investigate the value of low temperature plasma radiofrequency ablation(RFA)in the treatment of early glottic carcinoma(GC).Methods 98 patients with early GC were randomly divided into the control group(n=47)and the observation group(n=51).The control group was treated with conventional laryngectomy,and the observation group was treated with low temperature plasma RFA.The perioperative indexes,curative effect,complication rate and recurrence rate of the 2 groups were analyzed.The levels of voice acoustics(amplitude perturbation,fundamental frequency perturbation,harmonic noise ratio),serum matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF)and nitric oxide(NO)in the 2 groups were compared before and 3 months after surgery.Results The follow-up was ended in September 2023,and 1 case of the control group was lost to follow-up,1 case did not comply,and 45 cases were finally included.In the observation group,1 case dropped out,1 case was lost to follow-up,and 49 cases were finally included.There was no significant difference in the total effective rate and recurrence rate between the 2 groups(P>0.05).The operation time,wound epithelialization time and hospital stay of the control group were longer than that of the observation group,and the amount of intraoperative blood loss was higher than that of the observation group(P<0.05).3 months after operation,the amplitude disturbance and fundamental frequency disturbance in 2 groups were lower than before operation,and the harmonic noise ratio was higher than before operation.The harmonic noise ratio of the observation group was higher than that of the control group,and the fundamental frequency and amplitude perturbation were lower than that of the control group(P<0.05).The serum values of MMP-9,VEGF and NO in the 2 groups were lower than those before surgery 3 months after operation,and the above serum factors in the observation group were lower than those in control group(P<0.05).The complication rate of the control group was 20.00%,w

关 键 词：早期声门型喉癌 低温等离子射频消融术 血清预后因子 嗓音声学 

分 类 号：R739.65[医药卫生—肿瘤]