CT检查联合多种肿瘤标志物检测在非小细胞肺癌诊断中的应用研究  

Application of CT Examination Combined with Multiple Tumor Markers Detection in the Diagnosis of Non-small Cell Lung Cancer

作　　者：胡亚辉 吴静 陈锦威 HU Yahui;WU Jing;CHEN Jinwei(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学附属郑州中心医院,450000

出　　处：《实用癌症杂志》2024年第10期1684-1687,共4页The Practical Journal of Cancer

摘　　要：目的分析CT检查联合多种肿瘤标志物检测在非小细胞肺癌(NSCLC)诊断中的应用价值。方法选取97例NSCLC患者归入NSCLC组,同期97例良性肺部病变患者归入良性组。比较2组资料,包括CT检查结果和多种肿瘤标志物检测结果,分析CT检查联合多种肿瘤标志物检测在NSCLC诊断中的应用价值。结果NSCLC组达峰时间(Tp)低于良性组,强化峰值(PH)、主动脉强化峰值比肿块强化峰值(M/A)高于良性组,差异有统计学意义(P<0.05);NSCLC组血清细胞角质蛋白21-1片段(CYFA21-1)、糖类抗原125(CA125)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)高于良性组,差异有统计学意义(P<0.05)。经Logistic回归分析结果显示,CT检查参数Tp、PH、M/A和血清肿瘤标志物CYFA21-1、CA125、CEA、NSE水平均与NSCLC有关(P<0.05)。绘制ROC曲线发现,CT检查参数Tp、PH、M/A和血清肿瘤标志物CYFA21-1、CA125、CEA、NSE诊断NSCLC的AUC分别为0.733、0.821、0.676、0.938、0.930、0.934、0.918,均有一定诊断价值;联合CT检查结果、血清肿瘤标志物的AUC为0.977。结论CT检查联合多种肿瘤标志物检测在NSCLC诊断中的应用价值较高。Objective To analyze the application value of CT examination combined with multiple tumor marker detection in the diagnosis of non-small cell lung cancer(NSCLC).Methods 97 NSCLC patients who visited the hospital were selected and included in the NSCLC group.During the same period,97 patients with benign lung lesions were included in the benign group.Compare the 2 sets of data,including CT examination results and multiple tumor marker detection results,and analyze the application value of CT examination combined with multiple tumor marker detection in the diagnosis of NSCLC.Results The peak time(Tp)of the NSCLC group was lower than that of the benign group,while the enhancement peak(PH)and aortic enhancement peak to mass enhancement peak(M/A)were higher than those of the benign group,with statistically significant differences(P<0.05);Serum cytokeratin 21-1 fragment(CYFA21-1),carbohydrate antigen 125(CA125),Carcinoembryonic antigen(CEA),neuron specific Enolase(NSE)in NSCLC group were significantly higher than those in benign group(P<0.05);The results of logistic regression analysis showed that CT examination parameters Tp,PH,M/A,and serum tumor markers CYFA21-1,CA125,CEA,and NSE levels were all related to NSCLC(P<0.05);Drawing the Receiver operating characteristic,we found that the AUC of NSCLC diagnosed by CT parameters Tp,PH,M/A and serum tumor markers CYFA21-1,CA125,CEA,NSE were 0.733,0.821,0.676,0.938,0.930,0.934,0.918 respectively,which had certain diagnostic value.The AUC of NSCLC diagnosed by combining CT results with serum tumor markers was 0.977.Conclusion CT examination combined with multiple tumor markers detection has high application value in the diagnosis of NSCLC.

关 键 词：非小细胞肺癌 CT 肿瘤标志物 诊断 

分 类 号：R734.2[医药卫生—肿瘤]