环泊酚麻醉维持对早期胃癌内镜切除术患者麻醉效果及血流动力学的影响  

The Impacts of Ciprofol Anesthesia Maintenance on Anesthesia Effect and Hemodynamics in Patients Underwent Early Gastric Cancer Endoscopic Resection

作　　者：张伟 孙鼐[1] 杨晓晨 ZHANG Wei;SUN Nai;YANG Xiaochen(Zhengzhou Central Hospital,Zhengzhou,450007)

机构地区：[1]河南省郑州市中心医院,450007

出　　处：《实用癌症杂志》2024年第10期1699-1703,共5页The Practical Journal of Cancer

摘　　要：目的探究环泊酚麻醉维持对早期胃癌内镜切除术患者麻醉效果及血流动力学的影响。方法选取62例拟行内镜切除术的早期胃癌患者作为研究对象,并按随机数字表法分配为观察组(n=31)、对照组(n=31)。对照组麻醉诱导后使用丙泊酚进行麻醉维持,观察组麻醉诱导后使用环泊酚进行麻醉维持。比较2组患者的麻醉效果,包括麻醉生效时间、苏醒时间和麻醉室停留时间;比较2组患者麻醉前(T_(0))、麻醉后(T_(1))、进镜时间(T_(2))、意识恢复时(T_(3))的平均动脉压(MAP)以及心率(HR);比较2组患者手术前后的去甲肾上腺素(NE)和皮质素(Cor)的水平;比较2组患者术后清醒时、术后6、12、24 h的VAS疼痛评分和不良反应的发生情况。结果与对照组比较,观察组麻醉生效时间、苏醒时间、麻醉室停留时间均更短(P<0.05)。与T_(0)时相比,观察组和对照组T_(1)、T_(2)、T_(3)时MAP、HR水平均显著降低(P<0.05);T_(1)、T_(2)、T_(3)时MAP、HR水平观察组显著高于对照组(P<0.05)。与手术前相比,手术后观察组和对照组的NE、Cor水平显著升高(P<0.05),但观察组的NE、Cor水平显著低于对照组(P<0.05)。VAS评分在术后清醒时、术后6、12、24 h,观察组均低于对照组(P<0.05);呼吸抑制发生率观察组较对照组更低(P<0.05)。结论环泊酚用于早期胃癌内镜切除术的效果较好,可以更好地稳定血流动力学,减少应激反应,且安全性较高。Objective To study the effect of anesthesia maintenance with cypropofol on the anesthesia effect and hemodynamics in patients underwent endoscopic resection for early gastric cancer.Methods 62 patients with early gastric cancer who were proposed to underwent endoscopic resection were selected as study subjects and were allocated into the observation group(n=31)and the control group(n=31)according to the randomized numerical table method.Propofol was used for anesthesia maintenance after anesthesia induction in the control group,and cypropofol was used for anesthesia maintenance after anesthesia induction in the observation group.We compared the anesthesia effects of the 2 groups,including the time of anesthesia onset,the time of awakening,and the time of stay in the anesthesia room;we compared the mean arterial pressure(MAP)and the heart rate(HR)of the 2 groups at the time of pre-anesthesia(T_(0)),post-anesthesia(T_(1)),time of entry into the mirror(T_(2)),and time of recovery of consciousness(T_(3));we compared the levels of norepinephrine(NE)and corticosterone(Cor)before and after the operation;we compared the VAS pain scores and the incidence of adverse reactions at the time of postoperative wakefulness,6,12,and 24 h after surgery in the 2 groups.Results Compared with the control group,the time for anesthesia to take effect,the time for awakening,and the time for staying in the anesthesia room were shorter in the observation group(P<0.05).Compared with the time of T_(0),the levels of MAP and HR at T_(1),T_(2),and T_(3)were significantly lower in the observation and control groups(P<0.05);compared with the control group,the levels of MAP and HR at T_(1),T_(2),and T_(3)were significantly higher in the observation group than in the control group(P<0.05).Compared with the preoperative period,the NE and Cor levels were significantly higher in the observation group and the control group after surgery(P<0.05),but they were significantly lower in the observation group than in the control group(P<0.05).The VAS scores w

关 键 词：环泊酚 早期胃癌 内镜切除术 麻醉效果 血流动力学 

分 类 号：R735.2[医药卫生—肿瘤]