5-氨基酮戊酸光动力疗法联合咪喹莫特对皮肤基底细胞癌的疗效及对血清可溶性Fas、FasL水平的影响  

The Effect of 5-amino-ketovalerate Photodynamic Therapy Combined with Imiquimote on Skin Basal Cell Carcinoma and Serum Soluble Fas and FasL Levels

作　　者：田卓[1] 卞坤鹏 郭冰心 闫家笛 TIAN Zhuo;BIAN Kunpeng;GUO Bingxin(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《实用癌症杂志》2024年第10期1732-1735,共4页The Practical Journal of Cancer

摘　　要：目的探究5-氨基酮戊酸光动力疗法联合咪喹莫特对皮肤基底细胞癌的疗效及对血清可溶性Fas、FasL水平的影响。方法选取接受手术治疗的皮肤基底细胞癌患者96例,按随机数表法将其分为联合组(48例)与对照组(48例)。对照组患者单独采用5-氨基酮戊酸光动力疗法治疗6周,联合组患者采用5-氨基酮戊酸光动力疗法联合咪喹莫特涂抹治疗,持续治疗6周。比较两组患者治疗结束后临床疗效、伤口愈合情况、不良反应发生率以及患者治疗前后生活质量(GQOLI-74)评分及血清可溶性Fas和FasL水平。结果治疗结束后,联合组患者总有效率和伤口愈合率均高于对照组,差异有统计学意义(P<0.05)。治疗结束后,联合组和对照组患者生活质量各维度评分均升高,且联合组高于对照组,差异有统计学意义(P<0.05);联合组和对照组患者血清可溶性Fas和FasL水平均降低,且联合组低于对照组;差异有统计学意义(P<0.05)。治疗期间,联合组患者不良反应发生率与对照组相当,差异无统计学意义(P>0.05)。结论相比于单纯采用5-氨基酮戊酸光动力疗法治疗,5-氨基酮戊酸光动力疗法联合咪喹莫特涂抹治疗皮肤基底细胞癌临床效果更明显,可以降低血清可溶性Fas和FasL水平,提高患者生活质量。Objective To explore the effect of 5-amino-ketovalerate photodynamic therapy combined with imiquimote on skin basal cell carcinoma and serum soluble Fas and FasL levels.Methods A total of 96 patients with skin basal cell carcinoma were enrolled.According to random number table method,they were divided into combination group(48 cases)and the control group(48 cases).The control group was treated with 5-aminolevulinic acid photodynamic therapy,while combination group was additionally treated with imiquimod for 6 weeks.The clinical curative effect,wound healing and incidence of adverse reactions after treatment,scores of generic quality of life inventory-74(GQOLI-74)and levels of serum soluble Fas and FasL before and after treatment were compared between the 2 groups.Results After treatment,total response rate and wound healing rate in combination group were higher than those in the control group(P<0.05).After treatment,GQOLI-74 scores were increased in both groups,which were higher in combination group than the control group(P<0.05),and levels of serum soluble Fas and FasL were decreased,which were lower in combination group than the control group(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Compared with 5-aminolevulinic acid photodynamic therapy alone,clinical curative effect of 5-aminolevulinic acid photodynamic therapy combined with imiquimod is more significant in patients with skin basal cell carcinoma,which can reduce levels of serum soluble Fas and FasL,and improve quality of life.

关 键 词：氨基酮戊酸光动力疗法 咪喹莫特 皮肤基底细胞癌 

分 类 号：R739.5[医药卫生—肿瘤]