通关藤注射液治疗卵巢癌术后化疗患者的疗效  

Efficacy of Tongguanteng injection in the treatment of ovarian cancer patients undergoing postoperative chemotherapy

作　　者：申昌梅 张秋莲 阳纯平 SHEN Changmei;ZHANG Qiulian;YANG Chunping(Department of Gynecology Oncology,Ganzhou Cancer Hospital,Ganzhou 341000,Jiangxi,China;Department of Gynecology,Chongyi County Maternal and Child Health Care Hospital,Ganzhou 341399,Jiangxi,China)

机构地区：[1]赣州市肿瘤医院妇瘤科,江西赣州341000 [2]崇义县妇幼保健院妇科,江西赣州341399

出　　处：《癌症进展》2024年第16期1753-1756,共4页Oncology Progress

基　　金：江西省卫生健康委科技计划项目(202212538)。

摘　　要：目的探讨通关藤注射液治疗卵巢癌术后化疗患者的疗效。方法将80例卵巢癌患者随机分为通关藤组(n=40)和对照组(n=40)。两组患者均行卵巢癌手术及术后化疗,通关藤组患者联合通关藤注射液治疗。比较两组患者临床疗效、肿瘤标志物水平、细胞因子水平及不良反应发生率。结果通关藤组患者总有效率高于对照组,差异有统计学意义(P﹤0.05)。治疗后,两组患者糖类抗原125(CA125)、人附睾蛋白4(HE4)水平均较治疗前降低,且通关藤组患者CA125和HE4水平均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,通关藤组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)水平均较治疗前降低,对照组患者IL-6和IL-8水平均较治疗前降低,且通关藤组患者TNF-α、IL-6和IL-8水平均低于对照组,差异均有统计学意义(P﹤0.05)。通关藤组患者不良反应总发生率低于对照组,差异有统计学意义(P﹤0.05)。结论通关藤注射液可有效提高卵巢癌术后化疗患者的疗效,降低肿瘤标志物和细胞因子水平,减少化疗不良反应,可在临床上推广应用。Objective To investigate the efficacy of Tongguanteng injection in the treatment of of ovarian cancer pa-tients undergoing postoperative chemotherapy.Method A total of 80 patients with ovarian cancer were randomly divid-ed into Tongguanteng group(n=40)and control group(n=40).The two groups were treated with operation and postopera-tive chemotherapy for ovarian cancer,and the Tongguanteng group was treated with Tongguanteng injection.The effica-cy,tumor markers levels,cytokines levels and the occurrence of adverse reactions after chemotherapy were compared be-tween the two groups.Result The total effective rate of Tongguanteng group was higher than that of control group,the difference was statistically significant(P<0.05).After treatment,the levels of carbohydrate antigen 125(CA125)and hu-man epididymis protein 4(HE4)in two groups were lower than those before treatment,and the levels of CA125 and HE4 in Tongguanteng group were lower than those in control group,the differences were statistically significant(P<0.05).Af-ter treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in Tongguanteng group were lower than those before treatment,while the levels of IL-6 and IL-8 in control group were lower than those be-fore treatment,and the levels of TNF-α,IL-6 and IL-8 in Tongguanteng group were lower than those in control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in Tongguanteng group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion Tongguanteng in-jection can effectively improve the efficacy of postoperative chemotherapy in patients with ovarian cancer,reduce the lev-els of tumor markers and cytokines,and reduce the adverse reaction of postoperative chemotherapy,so it can be widely used in clinical practice.

关 键 词：通关藤注射液 卵巢癌 化疗 疗效 细胞因子 

分 类 号：R737.31[医药卫生—肿瘤]