中药鼻咽冲洗结合中药汤剂内服治疗鼻咽癌放射性鼻咽黏膜损伤患者的疗效  

Efficacy of TCM nasopharyngeal irrigation combined with oral administration of TCM decoction in the treatment of nasopharyngeal carcinoma patients with radiation-induced nasopharyngeal mucosal damage

作　　者：刘遗斌[1] 黄子葵[1] 罗冬[1] 游龙贵[1] 李欢 LIU Yibin;HUANG Zikui;LUO Dong;YOU Longgui;LI Huan(Department of Otorhinolaryngology Head and Neck Surgery,Ganzhou People’s Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市人民医院耳鼻咽喉头颈外科,江西赣州341000

出　　处：《癌症进展》2024年第16期1787-1790,共4页Oncology Progress

基　　金：江西省中医药管理局科技计划项目(2023B0801)。

摘　　要：目的探讨中药鼻咽冲洗结合中药汤剂内服治疗鼻咽癌放射性鼻咽黏膜损伤患者的临床疗效。方法采取乱数表法将100例鼻咽癌放射性鼻咽黏膜损伤患者分为研究组和对照组,每组50例,对照组患者给予中药鼻咽冲洗治疗,研究组患者给予中药鼻咽冲洗结合中药汤剂内服治疗。比较两组患者的临床疗效、黏膜损伤程度、疼痛程度[数字分级评分法(NRS)]、生活质量[欧洲癌症研究与治疗组织头颈癌生存质量测定量表(EORTC QLQ-H&N35)]。结果研究组患者的临床疗效优于对照组,差异有统计学意义(P﹤0.05)。治疗7周后,研究组患者的黏膜损伤程度明显低于对照组,差异有统计学意义(P﹤0.01)。治疗3、7周后,两组患者NRS评分均低于本组治疗前,研究组患者NRS评分均低于对照组,差异均有统计学意义(P﹤0.05)。治疗7周后,两组患者EORTC QLQ-H&N35评分均低于本组治疗前,研究组患者EORTC QLQ-H&N35评分低于对照组,差异均有统计学意义(P﹤0.05)。结论中药鼻咽冲洗结合中药汤剂内服治疗鼻咽癌放射性鼻咽黏膜损伤患者的疗效较为显著,能够有效减轻黏膜损伤和疼痛程度,提高生活质量。Objective To explore the clinical efficacy of traditional Chinese medicine(TCM)nasopharyngeal irrigation combined with oral administration of TCM decoction in the treatment of nasopharyngeal carcinoma patients with radiationinduced nasopharyngeal mucosal damage.Method A total of 100 nasopharyngeal carcinoma patients with radiation-induced nasopharyngeal mucosal damage were divided into study group and control group,with 50 cases in each group.Patients in the control group were given TCM nasopharyngeal irrigation,and patients in the study group were given TCM nasopharyngeal irrigation combined with oral administration of TCM decoction.The clinical efficacy,mucosal injury degree,pain degree[numerical rating scale(NRS]and quality of life[European Organization for Research and Treatment of Cancer head and neck cancer quality of life questionnaire(EORTC QLQ-H&N35)]were compared between the two groups.Result The clinical efficacy of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).After 7 weeks of treatment,the mucosal injury degree of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.01).After 3 and 7 weeks of treatment,the NRS scores in both groups were lower than those before treatment,and the NRS scores in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 7 weeks of treatment,the EORTC QLQ-H&N35 scores of the two groups were lower than those before treatment,and the EORTC QLQ-H&N35 score of the study group was lower than that of the control group,and the differences were statisti-cally significant(P<0.05).Conclusion TCM nasopharyngeal irrigation combined with oral administration of TCM de-coction is effective in the treatment of nasopharyngeal carcinoma patients with radiation-induced nasopharyngeal mucosal injury,which can effectively reduce mucosal injury and pain degree,and improve quality of life.

关 键 词：鼻咽黏膜损伤 鼻咽癌 中药鼻咽冲洗 中药汤剂内服 疼痛程度 生活质量 

分 类 号：R739.62[医药卫生—肿瘤]