AKT2在前列腺癌中的表达及与临床病理因素的关系  

Expression of AKT2 in prostate adenocarcinoma and its relationship with clinicopathological factors

作　　者：马志厚 华浩铭 朱娅男 黄岩 余娜 巩幼洁 陶司政 沈靖[1] 王红群 MA Zhi-hou;HUA Hao-ming;ZHU Ya-nan;HUANG Yan;YU Na;GONG You-jie;TAO Si-zheng;SHEN Jing;WANG Hong-qun(Department of Pathology,the Third People’s Hospital of Bengbu City,Bengbu 233099,China;Department of Pathology,the Second People’s Hospital of Bengbu City,Bengbu 233099,China;Department of Pathology,the Traditional Chinese Medicine Hospital of Bengbu City,Bengbu 233099,China)

机构地区：[1]蚌埠市第三人民医院(蚌埠市中心医院)病理科,安徽蚌埠233099 [2]蚌埠市第二人民医院病理科,安徽蚌埠233099 [3]蚌埠市中医院病理科,安徽蚌埠233099

出　　处：《诊断病理学杂志》2024年第9期842-846,共5页Chinese Journal of Diagnostic Pathology

基　　金：安徽省临床医学研究转化专项(202204295107020051)。

摘　　要：目的 探讨AKT2在前列腺腺癌中的表达意义,与临床病理因素的关系。方法 收集2017年1月至2023年6月蚌埠市第三人民医院诊断的76例前列腺腺癌及20例前列腺增生患者的临床病理资料和组织蜡块,采用免疫组化一步法En Vision,分析AKT2的表达与前列腺腺癌临床病理因素的关系。结果 AKT2在前列腺腺癌中的表达阳性率明显高于良性前列腺增生组织(61.8%vs.20.0%,P=0.001)。AKT2的表达随着核分裂象的增加阳性率增高,且与细胞质的嗜酸性明显有关(P均<0.05)。结论 AKT2表达与前列腺腺癌的发生及生长可能有一定关系,也有助于前列腺癌的诊断。Objective To explore the significance of AKT2 expression in prostate adenocarcinoma and its correlation with clinical pathological factors.Methods The clinical and pathological data and tissue wax blocks were collected from 76 prostate adenocarcinomas and 20 prostate hyperplasias.Using one-step immunohistochemistry EnVision method,AKT2 expression of prostate adenocarcinomas was detected and its relation with the clinical pathological factors was analyzed.Results The expression level of AKT2 in prostate adenocarcinomas was significantly higher than that in benign prostatic hyperplasia tissue(61.8%vs.20.0%,P=0.001).The expression of AKT2 increased with the increase of cell mitosis and was significantly related to the eosinophilic degeneration of the cytoplasm in prostate adenocarcinomas(P<0.05).Conclusion AKT2 may be related to the occurrence and growth of prostate adenocarcinoma,and has certain pathological diagnostic value.

关 键 词：前列腺腺癌 AKT2 免疫组化 核分裂象 

分 类 号：R737.25[医药卫生—肿瘤]