TRPS1在原发性乳腺外Paget病中的表达及其诊断价值  

Expression of TRPS1 in primary extramammary Paget disease and its diagnostic value

作　　者：毛学源 戚玉琴 佘欣远 黄旭 郑宇 王前玉 MAO Xue-yuan;QI Yu-qin;SHE Xin-yuan;HUANG Xu;ZHENG Yu;WANG Qian-yu(Department of Pathology,Suqian First Hospital,Suqian 223800,China)

机构地区：[1]宿迁市第一人民医院病理科,江苏宿迁223800

出　　处：《诊断病理学杂志》2024年第9期851-854,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的分析TRPS1在原发性乳腺外Paget病(EMPD)中的表达情况,探讨TRPS1在原发性EMPD诊断中的价值。方法收集宿迁市第一人民医院病理科2015年7月至2023年12月诊断的39例原发性EMPD、6例继发性EMPD、15例黑色素瘤和11例鳞状细胞原位癌病历资料,采用免疫组织化学En Vision法检测TRPS1的表达情况。结果原发性EMPD患者39例,男性29例,女性10例;年龄53~81岁(平均年龄68岁,中位年龄71岁)。继发性EMPD患者6例,男性4例,女性2例;年龄45~76岁(平均年龄59岁,中位年龄62.5岁)。39例原发性EMPD中,35例(35/39)显示TRPS1强和弥漫的细胞核表达,阳性率为89.7%,且4例阴性病例均位于肛周;而在6例继发性EMPD中均为阴性。TRPS1在15例黑色素瘤中也呈阴性,在90.9%(10/11)的鳞状细胞原位癌中表现为弥漫强阳性。本组病例中,TRPS1诊断原发性EMPD的敏感性和特异性分别为89.7%和68.8%。结论TPRS1在原发性EMPD中的表达具有高敏感性,有助于与继发性EMPD和黑色素瘤进行鉴别,但在原发性EMPD与鳞状细胞原位癌的鉴别中作用有限。Objective To study the expression of TRPS1 in primary extramammary Paget disease(EMPD),and to explore the value of TRPS1 in the diagnosis of primary EMPD.Methods Immunohistochemical EnVision method was used to detect the expression of TRPS1 in 39 cases of primary EMPD,6 cases of secondary EMPD,15 cases of melanoma and 11 cases of squamous cell carcinoma in situ diagnosed at the Department of Pathology of Suqian First Hospital from July 2015 to December 2023.Results Among the 39 patients with primary EMPD,there were 29 males and 10 females aged from 53 to 81 years(average age 68 years,median age 71 years).Among the 6 cases of secondary EMPD,there were 4 males and 2 females aged from 45 to 76 years(average age 59 years,median age 62.5 years).Of the 39 primary EMPD cases,35(35/39)showed strong and diffuse nuclear expression of TRPS1,with a positive rate of 89.7%,and the four negative cases were located in the perianal area;whereas,none of the 6 secondary EMPD cases showed any staining.TRPS1 was also negative in 15 cases of melanoma and showed diffuse strong positivity in 90.9%(10/11)of squamous cell carcinoma in situ.The sensitivity and specificity of TRPS1 for the diagnosis of primary EMPD in our cases were 89.7%and 68.8%,respectively.Conclusions The expression of TRPS1 has a high sensitivity in primary EMPD.TRPS1 may be useful to distinguish primary EMPD from secondary EMPD and melanoma,but its utility is limited in distinguishing it from squamous cell carcinoma in situ.

关 键 词：乳腺外PAGET病 免疫组织化学 TRPS1 外生殖器 腋窝 

分 类 号：R737.9[医药卫生—肿瘤]