基于中西医临床病证特点的鼻咽癌动物模型分析  

Analysis of animal model of nasopharyngeal carcinoma based on clinical symptoms of traditional Chinese and Western medicine

作　　者：张媛鑫 南硕 郭琳 王雪 苗明三[1] ZHANG Yuanxin;NAN Shuo;GUO Lin;WANG Xue;MIAO Mingsan(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《中华中医药杂志》2024年第9期4843-4847,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省重大公益专项(No.201300310100);河南省科技攻关项目(No.212102310351);河南省中医药科学研究专项课题(No.20-21ZYZD02)。

摘　　要：鼻咽癌发病率位于耳鼻咽喉科恶性肿瘤之首,临床表现有鼻塞、回涕带血、耳鸣、复视、头痛及颈部淋巴结肿大等。由于鼻咽癌发病位置的隐蔽性和肿瘤侵袭转移的生长特性,临床发现时多处于中晚期,延误了最佳治疗时机,因此,如何尽早实施治疗以及采取有效预防措施,成为鼻咽癌防治领域亟待解决的难题。实验动物为鼻咽癌发病机制及治疗措施研究提供了很好的模型。本研究通过查询数据库总结现有模型的品种、特征、造模方法,同时进行吻合度评价。结果发现,鼻咽癌的常用造模方法有化学药品二亚硝基哌嗪局部给药、感染EB病毒、注射细胞诱癌等,多是基于西医病因病机构建的模型,仅能表现部分疾病特征,与临床多因素致病存在较大出入,同时限制了中医药防治鼻咽癌的相关进展。因此,有必要改进现有模型,加入中医因素,构建基于中西医临床病证特点的动物模型,使其更贴合于临床实际,利于下一步疾病机制的研究。The incidence of nasopharyngeal carcinoma is the first among malignant tumors in the department of otolaryngology,with clinical manifestations including nasal congestion,bloody nose,tinnitus,double vision,headache and cervical lymph node enlargement,etc..Due to the hidden location of nasopharyngeal carcinoma and the growth characteristics of tumor invasion and metastasis,most patients were diagnosed in the middle and late stages,delaying the best treatment opportunity.How to implement treatment as soon as possible and take effective preventive measures has become an urgent problem in the field of prevention and treatment of nasopharyngeal cancer.Experimental animals provide a good model for the pathogenesis and treatment of nasopharyngeal carcinoma.This study summarized the varieties,characteristics and modeling methods of existing models by querying the database,and evaluated the coincidence.The results showed that the common modeling methods of nasopharyngeal carcinoma include local administration of chemical dinitropiperazine,infection with EB virus,and cell injection to induce cancer,etc..Most of them are based on the etiology and pathogenesis of Western medicine,which can only show part of the disease characteristics,which is different from the clinical multi-factor pathogenesis,and at the same time limit the relevant progress of traditional Chinese medicine prevention and treatment of nasopharyngeal carcinoma.Therefore,it is necessary to improve the existing model,add Chinese medicine factors,and build an animal model based on the clinical characteristics of traditional Chinese and Western medicine,so that it is more suitable for clinical practice and conducive to the next step of disease mechanismresearch.

关 键 词：鼻咽癌 动物模型 中西医结合 病证特点 

分 类 号：R739.63[医药卫生—肿瘤] R-332[医药卫生—临床医学]