牙周-正畸治疗对牙周炎致前牙移位患者牙周指标、骨代谢及血清sICAM-1、MCP-1水平的影响  

The impacts of periodontal-orthodontic treatment on periodontal indicators,bone metabolism and serum sICAM-1 and MCP-1 levels in patients with anterior tooth displacement(ATD)caused by periodontitis

作　　者：蔡晨雨 李媛媛 李苏娜 CAI Chenyu;LI Yuanyuan;LI Suna(Department of Orthodontic and Reconstructive,Hengshui People's Hospital,China,053000)

机构地区：[1]衡水市人民医院口腔正畸修复科,053000

出　　处：《实用口腔医学杂志》2024年第5期678-682,共5页Journal of Practical Stomatology

基　　金：衡水市科技计划项目(编号:2021014093Z)。

摘　　要：目的:探讨牙周-正畸治疗对牙周炎致前牙移位(ATD)患者牙周指标、骨代谢及血清人可溶性细胞间黏附分子(sICAM-1)、单核细胞趋化蛋白-1(MCP-1)水平的影响。方法:纳入60例牙周炎致ATD患者,随机分成对照组(n=30,牙周基础治疗+牙周夹板治疗)和牙周-正畸组(n=30,在对照组基础上联合正畸治疗)。另选取仅进行牙周基础治疗的31例ATD患者作为空白对照组。比较3组牙周探诊深度(PD)、菌斑指数(PLI)和牙龈指数(GI)、患牙松动度、骨代谢指标骨钙素(OCN)、护骨素(OPG)及血清炎症指标(sICAM-1、MCP-1)。结果:治疗6个月后,3组PD、PLI、GI及血清sICAM-1、MCP-1水平均低于治疗前(P<0.05),且牙周-正畸组均低于对照组、空白对照组(P<0.05);3组患牙松动度均优于治疗前(P<0.05),且牙周-正畸组优于对照组、空白对照组(P<0.05);3组OCN、OPG水平均高于治疗前(P<0.05),且牙周-正畸组均高于对照组、空白对照组(P<0.05)。结论:对牙周炎致ATD患者实施牙周-正畸治疗,可明显下调血清sICAM-1、MCP-1等炎症因子水平,有效调节骨代谢,使患者牙周功能得到良好改善。Objective:To investigate the impacts of periodontal-orthodontic treatment on periodontal indicators,bone metabolism and serum levels of soluble intercellular adhesion molecule-1(sICAM-1)and monocyte chemotactic protein-1(MCP-1)in patients with anterior tooth displacement(ATD)caused by periodontitis.Methods:60 patients with ATD caused by periodontitis were included and randomly divided into a reference group(n=30,periodontal basic treatment+periodontal splint treatment)and a study group(n=30,combination of orthodontic treatment with the reference treatment).31 ATD patients who only received periodontal basic treatment were included into the blank control group.The probing depth(PD),plaque index(PLI)and gingival index(GI),tooth looseness,bone metabolism indicators osteocalcin(OCN)and osteoprotegerin(OPG),and serum inflammatory indicators(sICAM-1 and MCP-1)were compared among the 3 groups before and after treatment.Results:After 6 months of treatment,the levels of PD,PLI,GI,and serum sICAM-1 and MCP-1 in the 3 groups were lower than those before treatment(P<0.05),and lower in the study group than in the reference group and blank control group(P<0.05);the looseness of the affected teeth in the 3 groups was decreased(P<0.05),and in the study group was less than in the reference group and blank control group(P<0.05);the levels of OCN and OPG in the 3 groups were higher(P<0.05)than those before treatment,and in the study group were higher than in the reference group and blank control group(P<0.05).Conclusion:Periodontal-orthodontic treatment can obviously reduce the levels of inflammatory factors in serum,effectively regulate bone metabolism and improve periodontal health in patients with ATD caused by periodontitis.

关 键 词：牙周夹板 正畸 牙周炎 前牙移位 骨代谢 牙周炎症 

分 类 号：R781.4[医药卫生—口腔医学]