急性胰腺炎肺损伤发病机制与程序性细胞死亡相关性的研究进展  

Research advances in pathogenesis of lung injury in acute pancreatitis and programmed cell death

作　　者：吴浪 宁守斌 陈升鑫 陈德鑫 李明阳[2] WU Lang;NING Shoubin;CHEN Shengxin;CHEN Dexin;LI Mingyang(Chinese PLA Medical School,Beijing 100853,China;Department of Gastroenterology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Gastroenterology,Air Force Medical Center,Beijing 100142,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一医学中心消化内科,北京100853 [3]空军特色医学中心消化内科,北京100142

出　　处：《解放军医学院学报》2024年第8期909-912,F0003,共5页Academic Journal of Chinese PLA Medical School

基　　金：首都临床特色诊疗技术研究及转化应用(Z221100007422061)。

摘　　要：急性胰腺炎为消化系统常见的急腹症,病情进展容易引起器官衰竭,严重者可危及生命,其中肺为重症急性胰腺炎最早且最常损伤的器官,目前治疗方法有限。已有大量研究阐明急性胰腺炎相关肺损伤的病理机制,如胰酶、激肽学说、细胞因子学说和微循环学说等,最新研究又丰富了致病机制。程序性细胞死亡是机体维持内环境稳定的一种主动调控方式,包括细胞凋亡、细胞坏死样凋亡、细胞焦亡和铁死亡等。大量研究发现细胞凋亡在急性胰腺炎肺损伤中起着重要作用,也有相关研究发现细胞坏死样凋亡和细胞焦亡是引起急性胰腺炎胰外器官细胞死亡的重要方式。本文从细胞凋亡、铁死亡、细胞焦亡和细胞坏死样凋亡出发,综述近几年急性胰腺炎肺损伤相关的程序性细胞死亡研究成果,旨在为其临床转化提供理论依据。Acute pancreatitis is a prevalent acute abdominal condition of the digestive system,which can lead to organ failure and be life-threatening in severe cases.Lung is the earliest and most frequently affected organ in severe acute pancreatitis,with limited treatment currently.While numerous studies have elucidated the pathogenic mechanisms underlying lung injury associated with acute pancreatitis,such as pancreatic enzyme theory,kinin theory,cytokine theory,and microcirculation theory,recent research has further enriched our understanding of the pathogenic mechanism.Programmed cell death actively regulates the stability of the body's internal environment and plays a crucial role in lung injury during acute pancreatitis.Apoptosis has been extensively studied in this context.Additionally,related studies have also identified necroptosis and pyroptosis as significant pathways leading to cell death in extrapancreatic organs during acute pancreatitis.Based on these findings regarding along with apoptosis,ferroptosis,pyroptosis,and necroptosis,this paper provides an overview of recent research results concerning programmed cell death related to lung injury in acute pancreatitis,aiming at offering theoretical references for future clinical applications.

关 键 词：急性胰腺炎 肺损伤 凋亡 铁死亡 焦亡 坏死样凋亡 

分 类 号：R576[医药卫生—消化系统]