结直肠锯齿状病变的研究进展  

Research progress of colorectal serrated lesions

作　　者：王上元 姜春萌[2] WANG Shangyuan;JIANG Chunmeng(Graduate School,Dalian Medical University,Dalian 116044,China;Department of Gastroenterology,the Second Hospital of Dalian Medical University,Dalian 116027,China)

机构地区：[1]大连医科大学研究生院,辽宁大连116044 [2]大连医科大学附属第二医院消化一科,辽宁大连116027

出　　处：《大连医科大学学报》2024年第4期357-361,367,共6页Journal of Dalian Medical University

摘　　要：结直肠锯齿状病变(CSL)是一类隐窝上皮呈锯齿状特征的异质性病变,根据WHO最新分类标准,CSL主要分为增生性息肉(HP)、无蒂锯齿状病变(SSL)和传统锯齿状腺瘤(TSA),后两者为结直肠癌(CRC)主要的癌前病变类型。通过锯齿状途径发生的癌变约占CRC的1/3。本文主要对CSL的病理分类、癌变途径、诊断、治疗及随访监测等方面进行综述,旨在提高对CSL的认识,为CRC的防治提供新思路。Colorectal serrated lesions(CSL) are a heterogeneous group of lesions characterized by serrated features in crypt epithelium. According to the latest WHO classification standards, CSL are mainly divided into hyperplastic polyps(HP), sessile serrated lesions(SSL) and traditional serrated adenomas(TSA), with the latter two being the main types of precancerous lesions in colorectum. Approximately one-third of colorectal cancer cases develop through the serrated pathway. This article mainly focuses on the pathological classification, carcinogenetic pathways, diagnosis, treatment, and follow-up monitoring of CSL,aiming to improve the understanding of CSLs and provide a new perspective for the prevention and treatment of colorectal cancer in the future.

关 键 词：锯齿状病变 结直肠癌 内镜特征 分子途径 

分 类 号：R574.6[医药卫生—消化系统]